牛膝总皂苷治疗膝骨关节炎的药理研究进展

Progress in Pharmacological Research on Total Saponins of Achyranthes bidentata in the Treatment of Knee Osteoarthritis

膝骨关节炎是关节组织降解和修复失衡,最终导致软骨退化、软骨下骨硬化、滑膜炎症的过程。现代医学的常用药物如止痛药、非甾体抗炎药、硫酸氨基葡萄糖和糖皮质激素类等只能暂时缓解膝骨关节炎的疼痛,但无法阻止关节炎的进展。牛膝是中医治疗膝骨关节炎的常见药物,牛膝总皂苷是其主要活性成分。近年研究发现牛膝总皂苷具有抗炎,抑制软骨基质降解等作用。该文对牛膝总皂苷治疗膝骨关节炎的药理研究成果作一综述,为临床治疗膝骨关节炎提供参考。

Knee osteoarthritis(KOA)is an active dynamic alteration arising from an imbalance between the repair and destruction of joint tissues, which results in cartilage degradation, subchondral sclerosis and synovial inflammation. Pharmacological agents include analgesics, non-steroidal anti-inflammatory drugs, glucosamine sulfate and corticosteroids, which are widely used in modern medicine to relieve symptoms but rarely delay structural progression of osteoarthritis. Dry roots of Achyranthes bidentata are commonly used in traditional Chinese medicine to treat KOA,and the total saponins of Achyranthes bidentata are its main active ingredients. Traditional Chinese medicine researchers have found that total saponins of Achyranthes bidentata have the effects of antiinflammation and suppressing cartilage degradation. To provide reference for clinical application,the current article reviewed the pharmacological progress of total saponins of Achyranthes bidentata in the treatment of KOA.