ceRNAs在甲状腺癌中的研究进展及展望

Progress of CeRNAs in thyroid carcinoma

甲状腺癌是世界上最为常见的内分泌恶性肿瘤之一,虽甲状腺癌患者总体生存率较佳,但发病率增速位列首位,故需深入了解甲状腺癌的发生发展机制,竞争内源性RNA(ceRNA)概念的提出进一步阐明了肿瘤发生的机制。目前研究表明环状RNA、长链非编码RNA、假基因转录本、mRNA均可作为ceRNAs参与ceRNA网络构建,它们拥有与编码蛋白(mRNA)相同的微小RNA反应元件(MRE),从而竞争结合微小RNA的结合位点,进而影响mRNA的表达来发挥促癌或抑癌的作用。近年来大量研究表明ceRNAs在甲状腺癌恶性行为中发挥重要作用,但少有学者对这些研究进行归纳梳理。本文旨在将这些与甲状腺癌相关的ceRNA分子进行总结,并阐明这些分子在甲状腺癌发生发展中的作用。

Thyroid carcinoma(TC)is one of the most prevalent endocrine malignancies worldwide.Patients with TC have high overall survival,but TC experienced the largest increase in incidence.Therefore,it is necessary to get further understanding of the mechanism involved in the development and progression of TC.The concept of the competing endogenous RNA(ceRNA)further illuminates the mechanism of tumorigenesis.Current studies indicate that psedugenic RNA,lncRNA,circRNA and mRNA,all of which may take part in the construction of ceRNETs as ceRNAs.These ceRNAs harbour the same miRNA response element(MRE)as mRNAs.Thus,ceRNAs can also competitively inhibit mRNA binding to the miRNAs,which results in affecting mRNA expression to exerts a pro-oncogenic or tumor-suppressive influence in tumor.Recently,a large number of studies have shown that ceRNA molecules play an important role in the malignant behavior of thyroid cancer.Therefore,it is necessary to summarize these studies.The purpose of this paper is to classify these ceRNA molecules in thyroid cancer and to elaborate the functions of these molecules in thyroid cancer.