探讨4种检验方法在丙肝诊断中的应用效果[包括丙肝抗体、丙肝病毒(HCV)RNA、白蛋白(ALB)及谷丙转氨酶(ALT)]

The Application Effect of Four Test Methods in the Diagnosis of Hepatitis C[Including Hepatitis C Antibody,Hepatitis C Virus(HCV)RNA,Albumin(ALB)and Alanine Aminotransferase(ALT)]

目的:研究丙肝抗体、丙肝病毒(HCV)RNA、白蛋白(ALB)及谷丙转氨酶(ALT)4种检验方法在丙肝诊断中的应用效果。方法:选取2015年1月~2019年12月某院收治的丙肝患者2260例,采集所有患者的空腹静脉血,进行丙肝抗体、丙肝病毒(HCV)RNA、白蛋白(ALB)及谷丙转氨酶(ALT)检测,分析不同检测结果的差异。结果:HCV-RNA检测阳性率显著高于丙肝抗体检测阳性率(P<0.05);随着HCV-RNA检测水平升高,ALB水平有不显著的降低;HCV-RNA阳性中有504例ALT异常,随着HCV-RNA检测水平上升ALT值也有明显上升。结论:丙肝抗体、HCV-RNA、白蛋白(ALB)及谷丙转氨酶(ALT)4种检验方法均可用于丙肝诊断,HCV-RNA是诊断中最重要的数据,联合丙肝抗体、HCV-RNA、白蛋白(ALB)、谷丙转氨酶(ALT)的检验效果更佳,具有较高的临床价值。

Objective:To study the application of four tests of hepatitis C antibody,hepatitis C virus(HCV)RNA,albumin(ALB),and alanine aminotransferase(ALT)in the diagnosis of hepatitis C.Methods:A total of 2260 HCV patients admitted to a hospital from January 2015 to December 2019 were collected,and fasting venous blood were collected from all patients for HCV antibodies,HCV RNA,albumin(ALB),and alanine aminotransferase(ALT)tests,then the difference of different test results were analyzed.Results:The positive rate of HCV-RNA detection was significantly higher than the positive rate of hepatitis C antibody detection(P<0.05).With the increase of HCV-RNA detection level,ALB levels did not decrease significantly.The ALT 504 cases of HCV-RNA positive was abnormal.As the detection level of HCV-RNA increases,the ALT value also increased significantly.Conclusion:The four tests of hepatitis C antibody,HCV-RNA,albumin(ALB),and alanine aminotransferase(ALT)can be used in the diagnosis of hepatitis C.HCV-RNA is the most important data in diagnosis,and the effect of combination test of hepatitis C antibody,HCV-RNA,albumin(ALB),and alanine aminotransferase(ALT)are better,with higher clinical value.