NGAL检测对急性肾小球肾炎早期肾损伤诊断的临床意义

The Clinical Significance of NGAL Detection in the Diagnosis of Early Renal Injury in Acute Glomerulonephritis

目的:探讨中性粒细胞明胶酶相关脂质运载蛋白(neutrophilgelatinase-associatedlipocalinNGAL,NGAL)检测对急性肾小球肾炎早期肾损伤诊断的临床意义。方法:选取2018年3月~2020年3月医院收治的88例急性肾小球肾炎相关早期肾损伤患者作为研究组,88例仅患急性肾小球肾炎患者作为对照组,检测并比较两组患者2、48h胱抑素、血和尿中性粒细胞明肢酶相关脂质运转蛋白等。结果:研究组患者入院后2、48h时胱抑素、血和尿NGAL均明显高于对照组,差异均有统计学意义(P<0.05);入院后7d时胱抑素、血和尿NGAL与对照组比较差异均无统计学意义(P>0.05)。结论:NGAL与急性肾小球肾炎相关早期肾损伤的产生和发展具有一定的关系,可通过检验诊断急性肾小球肾炎相关早期肾损伤情况。

Objective:To investigate the clinical significance of neutrophilgelatinase-associated lipocalinngal(NGAL)in the diagnosis of early renal injury in acute glomerulonephritis.Methods:88 patients with acute glomerulonephritis associated with early renal injury admitted to a hospital from March 2018 to March 2020 were selected as the study group,and 88 patients with acute glomerulonephritis only were selected as the control group.Detection and comparison of serum cystatin,blood and urine neutrophil limpase associated lipid operatin and so on after 2,48h were conducted in the two groups.Results:At 2 and 48h after admission,cystatin,blood and urine NGAL in the study group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).There were no statistically significant difference in cystatin,blood and urine NGAL between the two groups at 7 days after admission(P>0.05).Conclusion:NGAL is associated with the occurrence and development of early renal injury associated with acute glomerulonephritis,which can be diagnosed by testing.