慢性中耳炎患者真菌感染的发病原因和不同治疗方案的临床疗效

Causes of Fungal Infection in Patients with Chronic Otitis Media and Clinical Effects of Different Treatment Regimens

目的:对慢性中耳炎患者真菌感染的发病原因和不同治疗方案进行了研究。方法:将150例2018年1月~2019年12月内收治的慢性中耳炎患者视为研究对象展开,依据药物差异原则分为对照组和观察组,对照组行派瑞松单药治疗,观察组以对照组为基准,联合口服丹参酮治疗,观察对比两组临床疗效、临床指标用时、治疗后体征改善情况。结果:观察组临床疗效96.5%,对照组为85.7%(P<0.05);用药后观察组中耳积液改善时间、症状消失时间、治疗总时间等临床指标用时明显较低(P<0.05);用药治疗后观察组患者气导听阈、气骨导差体征恢复情况较高(P<0.05)。结论:自身因素、外界因素均可诱发慢性中耳炎患者出现真菌感染,而临床治疗疾病,建议在派瑞松单药治疗的基础上联合丹参酮治疗,在提高临床疗效、缩短临床指标用时、改善体征方面价值显著。

Objective:To study the etiology and treatment of fungal infection in patients with chronic otitis media.Methods:150 patients with chronic otitis media admitted from January 2018 to December 2019 were treated as subjects of the study.They were divided into two groups according to the principle of drug difference.The control group received single drug treatment of parisone,and the observation group was given oral danshinone therapy based on the control group,then the improvement of clinical efficacy,clinical indicators,and signs after treatment were observed.Results:The clinical efficacy was 96.5%in the observation group and 85.7%in the control group(P<0.05).The improvement time,symptom disappearance time,total treatment time and other clinical indicators of middle ear effusion in the observation group after medication were significantly lower(P<0.05).In the observation group,the recovery of air conduction auditory threshold and air bone conduction signs was better after treatment(P<0.05).Conclusion:Both internal and external factors can induce fungal infection in patients with chronic otitis media.For the clinical treatment of the disease,it is suggested to combine the treatment with tanshinone on the basis of the single drug treatment of parisone.It has significant value in improving clinical efficacy,shortening clinical index time and improving physical signs.