特发性肺动脉高压患者肺功能特点研究

Study on the characteristics of pulmonary function in patients with idiopathic pulmonary hypertension

目的:研究特发性肺动脉高压(IPAH)患者肺功能的特点。方法:2018年1月-2019年12月收治IPAH患者50例,并选取健康体检者50例作为对照组,进行肺功能(PFT)检查,研究IPAH患者肺功能特点。结果:IPAH患者第1秒用力呼气流量(FEV1/FVC)、第3秒呼气流量占预计值百分比(FEV3/FVC)、用力肺活量(FVC)、深吸气量(IC)、呼出25%肺活量时的最大呼气流量(MEF25)、呼出50%肺活量时的最大呼气流量(MEF50)、呼出75%肺活量时最大呼气流量(MEF75)、最大呼气中期流速(MMEF75/25)、肺弥散量(DLCO SB)低于对照组,差异有统计学意义(P<0.05);残气量占肺总量比值(RV/TLC)高于对照组,差异有统计学意义(P<0.05)。结论:与正常对照组相比,IPAH患者肺通气功能、肺弥散功能下降明显,肺残气量明显增加。

Objective:To study the characteristics of pulmonary function in patients with idiopathic pulmonary hypertension(IPAH).Methods:From January 2018 to December 2019,50 patients with IPAH were selected,and 50 healthy subjects were selected as the control group.Pulmonary function(PFT)examination was performed to study the characteristics of pulmonary function in patients with IPAH.Results:The forced expiratory flow in 1 second(FEV1/FVC),percentage of expiratory flow in 3 seconds to predicted value(FEV3/FVC),forced vital capacity(FVC),deep inspiratory volume(IC),maximum expiratory flow at exhaled 25%vital capacity(MEF 25),maximum expiratory flow at exhaled 50%vital capacity(MEF 50),maximum expiratory flow at exhaled 75%vital capacity(MEF 75),maximum mid-expiratory flow(MMEF 75/25)and lung diffusing capacity(DLCO SB)were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The ratio of residual volume to total lung volume(RV/TLC)in the control group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with the normal control group,the pulmonary ventilation function and pulmonary diffusion function decreased significantly,and the pulmonary residual volume increased significantly in patients with IPAH.