不同年龄段婴幼儿过敏性鼻炎的临床治疗策略

Clinical treatment strategy of allergic rhinitis in infants of different ages

目的:讨论不同年龄段婴幼儿过敏性鼻炎的临床治疗策略。方法:2017年7月-2019年7月收治过敏性鼻炎患儿200例,依据患儿年龄分为四组。A组年龄<6个月,采用盐水或海水清洗雾化等辅助治疗;B组年龄0.5~1岁,采用西替利嗪治疗;C组年龄2~3岁,采用西替利嗪+白三烯受体拮抗剂联合用药;D组年龄4~6岁,采用西替利嗪+鼻用糖皮质激素+白三烯受体拮抗剂联合用药。比较四组治疗效果。结果:A、B、C、D四组治疗总有效率分别为90.00%、92.00%、94.00%、92.00%,差异无统计学意义(P>0.05)。四组患儿治疗后嗜酸性粒细胞百分比均呈现下降趋势,与治疗前比较,差异有统计学意义(P<0.05);但四组患儿嗜酸性粒细胞百分比比较,差异无统计学意义(P>0.05)。结论:根据不同年龄段过敏性鼻炎采取不同治疗策略,可获得理想的治疗效果,且具有良好的安全性、依从性。

Objective:To explore the clinical treatment strategy of allergic rhinitis in infants of different ages.Methods:From July 2017 to July 2019,200 children with allergic rhinitis were selected and divided into four groups according to their age.Group A,aged<6 months,was treated with adjuvant therapy such as saline or seawater cleaning atomization.Group B,aged 0.5~1 year,was treated with cetirizine.Group C,aged 2~3 years,was treated with cetirizine plus leukotriene receptor antagonist.Group D,aged 4~6 years,was treated with cetirizine,nasal glucocorticoid and leukotriene receptor antagonist.We compared the therapeutic effects of the four groups.Results:The total effective rates of group A,B,C and D were 90.00%,92.00%,94.00%and 92.00%respectively,the difference was not statistically significant(P>0.05).After treatment,the percentage of eosinophils in the four groups showed a significant downward trend,compared with before treatment,the difference was statistically significant(P<0.05).But there was no significant difference in the percentage of eosinophils among the four groups(P>0.05).Conclusion:According to different age groups of patients with allergic rhinitis,different treatment strategies can not only obtain the ideal treatment effect,but also make the treatment have good safety and compliance.