CAG方案联合去甲基化药物治疗复发性白血病的临床效果分析

Clinical effect of CAG regimen combined with demethylation drugs in the treatment of recurrent leukemia

目的分析CAG方案联合去甲基化药物(HMA)治疗复发性白血病的临床效果。方法抽取2017年1月至2018年1月郑州大学第二附属医院收治的62例复发性白血病患者,随机分为对照组和观察组,每组31例。对照组采用CAG方案,观察组在对照组基础上联合HMA,均治疗1个疗程,并随访2年。记录并比较两组治疗效果;检测并比较治疗前后两组血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(bFGF)水平;记录并比较治疗期间两组不良反应;记录两组随访2年的生存情况。结果观察组临床缓解率高于对照组(P<0.05);疗程结束时,两组VEGF、bFGF水低于治疗前,且观察组低于对照组(P<0.05);两组不良反应发生率比较差异未见统计学意义(P>0.05);随访结束,两组生存率比较差异未见统计学意义(P>0.05);观察组生存时间长于对照组(P<0.05)。结论CAG方案联合去甲基化药物治疗复发性白血病,更利于提高治疗效果,且安全可靠,患者血清生长因子水平降低、生存时间增加。

Objective To analyze the effect of CAG regimen combined with hypomethylating agents(HMA)in the treatment of recurrent leukemia.Methods Sixty-two patients with recurrent leukemia treated in the Second Affiliated Hospital of Zhengzhou University from January 2017 to January 2018 were selected.According to the random number table method,they were divided into control group and observation group,with 31 cases in each group.The control group was treated with CAG regimen,and the observation group was treated with HMA on the basis of the control group.All were treated for a course of treatment and followed up for 2 years.The treatment effects of the two groups were recorded and compared before and after treatment,the levels of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in the two groups were detected and compared;during treatment,the toxic and side effects of the two groups were recorded and compared;the survival status of the two groups during the 2-year follow-up was recorded.Results The clinical remission rate of the observation group was higher than that of the control group(P<0.05);at the end of the treatment course,the levels of VEGF and bFGF of the two groups were lower than before treatment,and those in the observation group was lower than those of the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05);after follow-up,there was no significant difference in survival rate between the two groups(P>0.05);the survival time of the observation group was longer than that of the control group(P<0.05).Conclusions CAG regimen combined with demethylation drugs in the treatment of recurrent leukemia is more conducive to improve the therapeutic effect,and it is safe and reliable,with lower serum growth factor level and longer survival time.