七氟烷联合丙泊酚麻醉对非小细胞肺癌胸腔镜切除术患者血清炎性因子及氧化应激水平的影响

Effect of combination of sevoflurane and propofol on serum inflammatory factors and oxidative stress in patients with non-small cell lung neoplasms undergoing thoracoscopic resection

目的分析七氟烷联合丙泊酚麻醉对非小细胞肺癌胸腔镜切除术患者血清炎性因子及氧化应激水平的影响。方法抽取2018年10月至2020年5月于郑州人民医院行非小细胞肺癌胸腔镜切除术治疗的80例患者,按照手术进行的先后顺序分为两组,每组40例。将接受单纯丙泊酚麻醉维持的患者作为对照组,将另外接受七氟烷联合丙泊酚麻醉维持的患者作为观察组,比较两组非小细胞肺癌患者的血清炎性因子水平、氧化应激情况、简易智力状态评价量表(MMSE)评分以及视觉模拟评分法(VAS)评分。结果观察组治疗后白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、肿瘤坏死因子α(INF-α)等血清炎性因子水平低于对照组(P<0.05);治疗后,观察组超氧化物歧化酶(SOD)、丙二醛(MDA)等氧化应激水平低于对照组,总抗氧化能力(T-AOC)水平高于观察组(P<0.05);接受不同方法麻醉后,观察组MMSE评分、VAS评分均低于对照组(P<0.05)。结论非小细胞肺癌患者接受胸腔镜切除术治疗的过程中应用七氟烷联合丙泊酚麻醉维持,能降低患者血清炎性因子和氧化应激因子水平,维持患者机体稳定性,减少对患者精神状态的影响,镇痛效果十分显著。

Objective To analyze the effect of sevoflurane combined with propofol on serum inflammatory factors and oxidative stress in patients with non-small cell lung neoplasms undergoing thoracoscopic resection.Methods Eighty patients with non-small cell lung neoplasms who underwent VATS in Zhengzhou People’s Hospital from October 2018 to May 2020 were selected.According to the sequence of operation,the patients were divided into two groups,40 patients in each group.Patients who were maintained with propofol alone were assigned to the control group,and those who were maintained with sevoflurane combined with propofol were assigned to the observation group.Serum inflammatory factor levels,oxidative stress,mini-mental state examination(MMSE)scores,and visual analogue scale(VAS)scores were compared between the two groups.Results The serum levels of interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor alpha(INF-α)and other inflammatory factors after operation in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the oxidative stress levels of superoxide dismutase(SOD),malondialdehyde(MDA)in the observation group were lower than those in the control group,and the oxidative stress levels of total anti-oxidation capacity(T-AOC)were higher than those in the observation group(P<0.05).After different anesthesia,MMSE and VAS scores of patients in the observation group were lower than those in the control group(P<0.05).Conclusions Patients with non-small cell lung neoplasms underwent thoracoscope treatment in the process of the application of combined propofol sevoflurane anesthesia,can reduce the patients,the serum levels of inflammatory factor and oxidative stress factor to maintain body’s stability,reduce the impact on patients’mental state,analgesic effect is significant.