两种不同剂量甲强龙分别联合头孢曲松抗感染治疗小儿支原体肺炎疗效

Effect of two different doses of methylprednisolone combined with ceftriaxone in the treatment of mycoplasma pneumonia in children

目的分析两种不同剂量甲强龙分别联合头孢曲松抗感染治疗小儿支原体肺炎的临床疗效。方法选用2019年4月-2020年4月期间于本院接受治疗的支原体肺炎患儿共80例作为研究对象,采用随机数字分配的方式将患儿分为两组,对照组实施2mg/kg甲强龙联合头孢曲松抗感染治疗,观察组实施20mg/kg甲强龙联合头孢曲松抗感染治疗,比较两组患儿治疗有效率及治疗后临床症状体征改善时间。结果观察组患儿治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后临床症状体征改善时间优于对照组,差异有统计学意义(P<0.05)。结论头孢曲松是治疗小儿支原体肺炎最常见抗感染药物,将头孢曲松与甲强龙(注射用甲泼尼龙琥珀酸钠)联合使用后可以达到更为理想的治疗效果,而20mg/kg甲强龙与2mg/kg甲强龙相比较其效果更佳,可以促进患儿康复,故在临床应用中具有广阔的发展前景。

Objective The clinical efficacy of two different doses of methylprednisolone combined with ceftriaxone in the treatment of mycoplasma pneumonia in children was analyzed.Methods Using 80 cases of mycoplasma pneumonia treated in our hospital from April 2019 to April 2020,the children were divided into two groups by random number distribution, the control group was treated with 2 mg/kg of methylprednisolone combined with ceftriaxone anti-infection treatment, the observation group was treated with 20 mg/kg of methylprednisolone combined with ceftriaxone anti-infection treatment, and the effective rate of treatment and the improvement time of clinical symptoms and signs were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group(P<0.05),and the improvement time of clinical symptoms and signs in the observation group was better than that in the control group(P<0.05).Conclusion Ceftriaxone is the most common anti-infective drug in the treatment of mycoplasma pneumonia in children.the combination of ceftriaxone and methylprednisolone(methylprednisolone sodium succinate for injection) can achieve a more ideal therapeutic effect.compared with 20 mg/kg methylprednisolone and 2 mg/kg methylprednisolone, the effect is better and can promote the recovery of children, so it has a broad development prospect in clinical application.