细胞焦亡与新生儿脑损伤

Pyroptosis and neonatal brain injury:a review

细胞焦亡是近年来新发现的一种程序性细胞死亡方式。动物研究表明,细胞焦亡参与了各种原因导致脑损伤的发生发展。抑制细胞焦亡可减轻动物的神经系统症状,发挥神经系统保护作用。细胞焦亡可能为临床治疗新生儿脑损伤提供靶点。现综述细胞焦亡及其在各类脑损伤的致病机制,以加深临床医师对新生儿脑损伤的认识。

Pyroptosis is a way of programmed cell death which is newly discovered in recent years.Animal studies have shown that pyroptosis is involved in the occurrence and development of brain injury from various causes.Inhibition of pyroptosis plays a protective role in the nervous system in animal models by reducing the neurological symptoms.Pyroptosis may provide a target for clinical treatment of neonatal brain injury.This paper reviews pyroptosis's mechanism and its role in the pathogenesis in brain injury in various conditions for a better understanding of neonatal brain injury.