综合有机化学实验:生物碱essramycin类似物的合成与表征

Comprehensive Organic Chemistry Experiment:Synthesis and Characterization of Essramycin Analogue

以乙酰乙酸乙酯和5-氨基-1H-1,2,4-三氮唑-3-羧酸甲酯为原料,经过系列官能团转化和环合,制备出带有多种衍生化基团(如酰肼)的生物碱essramycin类似物。实验涉及加热回流、真空脱溶、抽滤和TLC检测等基础操作,可以锻炼学生在有机化合物合成、纯化及结构鉴定等方面的操作技能。实验要求学生独立查阅文献,熟练掌握ChemDraw和MestReC等软件的使用,可以提升学生分析问题并解决问题的能力。实验以提高本科生综合素质为宗旨,适用于学生综合有机化学实验。

Starting from ethyl acetoacetate and methyl 5-amino-1H-1,2,4-triazole-3-carboxylate,essramycin analogues with various derivable groups(such as hydrazide)were successfully prepared by functional group transformation and cyclization reaction.The experiment involves basic operations,such as heating reflux,vacuum desolvation,filtration and TLC detection,to train students’operational skills in the synthesis,purification and structural identification of organic compounds.Students were required to consult literature independently and master the use of ChemDraw and MestReC software to improve their ability to analyze and solve problems.The purpose of the experiment is to improve the comprehensive quality of undergraduates,which is suitable for students’comprehensive organic chemistry experiments.