摘要
以乙酰乙酸乙酯和5-氨基-1H-1,2,4-三氮唑-3-羧酸甲酯为原料,经过系列官能团转化和环合,制备出带有多种衍生化基团(如酰肼)的生物碱essramycin类似物。实验涉及加热回流、真空脱溶、抽滤和TLC检测等基础操作,可以锻炼学生在有机化合物合成、纯化及结构鉴定等方面的操作技能。实验要求学生独立查阅文献,熟练掌握ChemDraw和MestReC等软件的使用,可以提升学生分析问题并解决问题的能力。实验以提高本科生综合素质为宗旨,适用于学生综合有机化学实验。
Starting from ethyl acetoacetate and methyl 5-amino-1H-1,2,4-triazole-3-carboxylate,essramycin analogues with various derivable groups(such as hydrazide)were successfully prepared by functional group transformation and cyclization reaction.The experiment involves basic operations,such as heating reflux,vacuum desolvation,filtration and TLC detection,to train students’operational skills in the synthesis,purification and structural identification of organic compounds.Students were required to consult literature independently and master the use of ChemDraw and MestReC software to improve their ability to analyze and solve problems.The purpose of the experiment is to improve the comprehensive quality of undergraduates,which is suitable for students’comprehensive organic chemistry experiments.
作者
卢爱党
彭文浩
张东升
李红岩
LU Ai-Dang;PENG Wen-Hao;ZHANG Dong-Sheng;LI Hong-Yan(School of Chemical Engineering.Hebei University of Technology,Tianjin 300130,China;National-Local Joint Enginecring Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization,Tianjin 300130,China)
出处
《化学教育(中英文)》
CAS
北大核心
2021年第8期63-68,共6页
Chinese Journal of Chemical Education
基金
河北省自然科学基金(B2020202028)
河北工业大学教育教学改革项目
河北工业大学一流专业建设专项基金
本科优质课建设项目。
关键词
综合有机化学实验
essramycin类似物
缩合反应
官能团的转化
comprehensive organic chemistry experiment
essramycin analogue
condensation reaction
transformation of functional groups