新型冠状病毒肺炎患者新型冠状病毒抗体持续阳性时间的影响因素

Influencing factors of persistent SARS-CoV-2 antibody positive test results in patients with COVID-19

目的分析影响新型冠状病毒肺炎(COVID-19)患者的新型冠状病毒(SARS-CoV-2)抗体持续阳性时间的影响因素。方法回顾性分析我院于2020年1月21日至10月25日收治并随访时间超过6个月的43例COVID-19患者,比较发病后随访6个月时抗体转阴组患者与持续阳性组患者的临床特点。结果随访超过6个月的43例患者中,有10例(25.6%)患者SARS-CoV-2 IgM和IgG均转阴,抗体持续阳性患者的年龄较大、淋巴细胞计数较低、发热比例较高(P <0.05);多因素回归分析显示淋巴细胞计数较低、发热是患者抗体持续阳性超过6个月的独立危险因素。结论淋巴细胞计数偏低、发热的COVID-19患者的抗体阳性持续时间更长。

Objective To investigate the factors affecting the positive duration of SARS-CoV-2 antibody in patients with COVID-19.Methods A retrospective analysis was made among 43 patients with COVID-19 who were followed up for more than 6 months in our hospital from January 21 to October 25,2020.The clinical characteristics were compared between those patients with antibody negative test results and those with persistent positive test results after 6 months of follow-up.Results After follow-up of over 6 months,both SARS-CoV-2 IgM and IgG tested negative in 10 patients,taking up 25.6%.The patients tested persistently positive were characterized by old age,lower lymphocyte count and higher incidence rate of fever(P <0.05).Multivariate regression analysis showed that lower lymphocyte count and fever were independently related to the persistent antibody positive test resultsfor more than 6 months.Conclusion The persistent antibody positive test results in COVID-19 patients account for low lymphocyte count and fever.