circRNA调控放疗抵抗相关通路的作用机制研究进展

Research progress on the mechanism of circRNA regulating radioresistance-related pathways

放射治疗是目前临床上治疗恶性肿瘤的重要手段,但是肿瘤细胞由此产生的放疗抵抗不仅严重限制了肿瘤放射治疗的效果,导致患者预后不良,最终可能造成患者出现肿瘤转移复发等状况.环状RNA (circRNA)是非编码RNA中的新成员,具有高度特异性、稳定性和保守性.本文从circRNA对放疗抵抗相关信号通路影响入手,从DNA损伤修复通路、EMT(上皮间质转化)过程、Wnt通路、肿瘤干细胞等通路变化的角度,梳理circRNA在肿瘤细胞对放疗抵抗的作用机制,为进一步研究circRNA提供有价值的线索.

Radiotherapy is an important means to treat malignant tumors in clinical practice.However,tumor radioresistance not only seriously limits the efficiency of radiotherapy,but also leads to poor prognosis of patients,which may eventually lead to tumor metastasis and recurrence.Circular RNA(circRNA)is a new member of noncoding RNA,which is highly specific,stable and conservative.This paper reviewed with the effect of circRNA on the signal pathways related to radiotherapy resistance by analyzing the perspective of DNA damage repair pathway,EMT(epithelial mesenchymal transition)process,Wnt pathway,tumor stem cells and other pathways,and sorted out the mechanism of circRNA in tumor cell resistance to radiotherapy,which may provide valuable clues for further study of circRNA.