间充质干细胞治疗放射性肺纤维化的研究进展

Progress in the treatment of radiation-induced pulmonary fibrosis with mesenchymal stem cells

放射性肺纤维化是胸腔肿瘤放疗的一种常见并发症,主要表现为肺间质慢性进行性实变,可导致患者肺部生理功能减退乃至丧失,严重者引起呼吸衰竭而死亡.近年研究发现,间充质干细胞能够通过分化为功能细胞、分泌细胞因子以及调节肺部免疫细胞的活性,在治疗放射性肺纤维化中发挥作用.因此,MSC作为一种细胞治疗手段在RIPF上有着良好的应用前景.本文就MSC治疗RIPF的分子机制、影响因素及应用现状进行综述.

Radiation-induced pulmonary fibrosis(RIPF)is a common complication of thoracic tumor radiotherapy.The main manifestation of radiation-induced pulmonary fibrosis is chronic progressive consolidation of pulmonary interstitium,which may cause the lung physiology function reduced or even lost.Furthermore,it can be lethal forrespiratory failure in severe cases.Recent studies have found that mesenchymal stem cells(MSC)play an important role in the modulation of proliferation and the activation of immune cells in lung inflammation.In addition,MSC can also play a part in the treatment of RIPF by differentiating into functional cells and secreting cytokines.Therefore,MSC has a good application prospect in RIPF as a cell therapy method.This article reviews the molecular mechanisms,influencing factors and current status of MSC therapy in RIPF.