腹腔镜下结直肠癌根治术对免疫功能及术后恢复的影响

Study on immune function and postoperative recovery after laparoscopic radical resection of colorectal cancer

目的:研究腹腔镜下结直肠癌根治术对免疫功能及术后恢复的影响。方法:选取2018-01~2020-06收治的60例结直肠癌患者,随机分为观察组和对照组,每组各30例。观察组行腹腔镜下结直肠癌根治术,对照组行开腹结直肠癌根治术,比较两种术式的围手术期相关指标、手术前后T淋巴细胞亚群、术后并发症,利用SPSS20.0统计软件进行数据统计分析,比较各组数据有无统计学差异。结果:观察组的手术时间长于对照组的手术时间,但差异不显著(P>0.05);观察组术中出血量、术后排气时间及住院时间均低于对照组,且差异显著(P<0.05);观察组和对照组的术前CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)差异均不显著(P>0.05);观察组术后CD3^(+)、CD4^(+)高于对照组,观察组术后CD8^(+)、CD4^(+)/CD8^(+)低于对照组,差异显著(P<0.05);观察组术后并发症2例,低于对照组6例,但差异不显著(P=0.129)。结论:相较于传统开腹手术,腹腔镜下结直肠癌根治术能降低术中出血量和住院时间,更好的改善患者免疫功能,减少并发症,利于患者恢复。

Objective:To study the immune function and postoperative recovery after laparoscopic radical resection of colorectal cancer.Methods:A total of 60 patients with colorectal cancer admitted to Changzhou Seventh People's Hospital from December 2018 to November 2020 were selected and randomly divided into observation group and control group,with 30 cases in each group.The observation group received laparoscopic radical resection of colorectal cancer,and the control group received open radical resection of colorectal cancer.SPSS20.0 statistical software was used for statistical analysis of the data,and the perioperative related indexes,T lymphocyte subsets before and after surgery and postoperative complications of the two surgical methods were compared.Results:The operation time of the observation group was longer than that of the control group,but the difference was not statistically significant(P>0.05).The amount of intraoperative blood loss,postoperative exhaust time and length of hospital stay in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in preoperative CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the observation group and the control group(P>0.05).CD3^(+)and CD4^(+)in the observation group were higher than those in the control group,while CD8^(+)and CD4^(+)/CD8^(+)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Two cases of postoperative complications in the observation group were lower than those in the control group(6 cases),but the difference was not statistically significant((P=0.129).Conclusion:Compared with traditional open surgery,laparoscopic radical resection of colorectal cancer can reduce intraoperative blood loss and length of stay,better improve the immune function of patients,reduce complications,and benefit the recovery of patients.