摘要
Dear Editor,Signal transduction takes the responsibility of translating extracellular information into specific cellular activities,enabling cells,including cancer cells,to respond exquisitely to extracellular guidance cues.N6-methyladenosine(m^(6)A),the most pervasive and abundant modification within eukaryotic mRNAs,is known to have specific effects on cellular activities relevant to cancer.1 Despite the fact that m^(6)A methylation is a dynamic event involving a series of enzymes,it remains unknown whether signal transduction,much less extracellular signaling molecules,uses m^(6)A methylation as an effector mechanism in cancer.
基金
supported by grants from the National Natural Science Foundation of China(81802391 to Q.G.,81872313 and 81672776 to Y.L.,and 61973003 to R.Y.)
Natural Science Foundation of Anhui Province(1808085QH266 to Q.G.)
Anhui Provincial Key Laboratory Performance Project(2017070503B041 and 2018080503B0031 to S.H.).
