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Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1a 被引量:2

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摘要 Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high malignancy.Nearly one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the mechanism for the development of CRC,in order to find more effective diagnosis markers and therapeutic targets.Various RNA modifications have been identified in both mRNA and non-coding RNAs,with RNA methylation being the most common mRNA modification in eukaryotes.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第3期624-626,共3页 信号转导与靶向治疗(英文)
基金 funded by Outstanding Clinical Discipline Project of Shanghai Pudong(No.PWYgy-2018-08) Program for Medical Key Departments of Shanghai(No.ZK2019A10) Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling(No.zdsys202002) Committee of Shanghai Science and Technology(Nos.18ZR1433900 and 17DZ2200200) Discipline Construction Promoting Project of Shanghai Pudong Hospital(Zdxk2020-01) Academic Leaders Training Program Supported by Pudong Health Bureau of Shanghai(No.PWRd2016-05) Specialty Feature Construction Project of Pudong Health and Family Planning Commission of Shanghai(No.PWZzb2017-21).
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