卡培他滨不同给药方案用于晚期消化道肿瘤的治疗效果

Effect of different Capecitabine administration regimens in the treatment of advanced gastrointestinal tumors

目的探讨卡培他滨不同给药方案用于晚期消化道肿瘤的治疗效果。方法选取2017年1月~2019年3月陆军军医大学特色医学中心消化内科收治的100例晚期消化道肿瘤患者作为研究对象,按照随机数字表法分为试验组(50例)和对照组(50例)。对照组采用2500 mg/m^(2)卡培他滨治疗,试验组采用2000 mg/m^(2)卡培他滨治疗,比较两组患者治疗效果及不良反应发生情况。结果试验组的总有效率为80.00%,高于对照组的62.00%,差异有统计学意义(P<0.05);试验组不良反应总发生率为22.00%,低于对照组的48.00%,差异有统计学意义(P<0.05)。结论相较于卡培他滨2500 mg/m^(2)治疗,晚期消化道肿瘤患者接受卡培他滨2000 mg/m^(2)治疗,可提高患者的治疗效果,降低不良反应发生率,安全有效。

Objective To investigate the therapeutic effect of Capecitabine in patients with advanced digestive tract tumor.Methods A total of 100 patients with advanced digestive tract tumor admitted to Department of Gastroenterology,Special Medical Center of PLA Military Medical University from January 2017 to March 2019 were selected as the research subjects,and they were divided into experimental group(50 cases)and control group(50 cases)according to random number table method.The control group was treated with 2500 mg/m^(2) Capecitabine,and the experimental group was treated with 2000 mg/m^(2) Capecitabine.The treatment effect and the incidence of adverse reaction were compared between the two groups.Results The total effective rate of experimental group was 80.00%,which was higher than that of control group(62.00%),the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the test group was 22.00%,which was lower than 48.00%in the control group,the difference was statistically significant(P<0.05).Conclusion Compared with 2500 mg/m^(2) Capecitabine treatment,patients with advanced gastrointestinal cancer receiving 2000 mg/m^(2) Capecitabine treatment can improve the treatment effect and reduce the incidence of adverse reactions,which is safe and effective.