MRI对肝纤维化及肝硬化定量评估的研究进展

Progress in quantitative assessment of liver fibrosis and cirrhosis by MRI

肝纤维化是一种可逆的创伤修复反应,肝纤维化的早期发现和分期可以降低其危险性。肝硬化作为肝纤维化的终末期,若未得到及时有效地干预,肝硬化会引起一系列严重的并发症。对于肝纤维化和肝硬化的评估,MRI检查比病理和血液生化学指标能够更直观、全面地反映肝脏的变化。作者主要对扩散加权成像、钆塞酸二钠增强成像、磁共振弹性成像的技术原理以及定量评估肝纤维化和肝硬化的研究进展进行综述。

Liver fibrosis is a reversible wound repair response.Early detection and staging of liver fibrosis can reduce its risk.As the end stage of liver fibrosis,cirrhosis will cause a series of serious complications if not timely and effective intervention.For the assessment of liver fibrosis and cirrhosis,MRI examination can reflect the changes of liver more directly and comprehensively than pathological and blood biochemical indexes.This article mainly reviews the technical principles of diffusion-weighted imaging(DWI),gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced imaging,magnetic resonance elastography(MRE)and the research progress in the evaluation of liver fibrosis and cirrhosis.