T细胞免疫球蛋白黏蛋白分子1在脓毒症发病机制中的作用研究进展

Research progress of T cell immunoglobulin mucin molecule 1 in the pathogenesis of sepsis

脓毒症3.0的定义为宿主对感染的失控反应而引起的危及生命的器官功能障碍,其发病率和病死率均较高,预后较差,是导致重症患者死亡的主要原因之一。由于目前人们对脓毒症发病机制的认识尚不足,导致对脓毒症的治疗缺乏特异性。而T细胞免疫球蛋白黏蛋白分子(Tim)家族中的Tim-1在脓毒症炎症反应、免疫耐受和细胞凋亡等一系列病理生理改变中起关键作用,并且是预测脓毒症患者预后及疗效评估中特异性相对较高的生物指标,为脓毒症的免疫治疗提供了新靶点,也为脓毒症发病机制的基础研究提供了一个新方向。现就Tim-1的发现和Tim-1的结构、分布与其免疫效应,Tim-1在脓毒症免疫抑制期、淋巴细胞增殖和细胞凋亡中的可能作用,以及未来Tim-1在脓毒症中作用的研究空间进行综述,以期为脓毒症的治疗提供参考。

Sepsis 3.0 is defined as a life-threatening organ dysfunction caused by the host'uncontrol response to infection,with poor prognosis,high morbidity and fatality.Sepsis is one of the main causes of death in severe patients.As lack of comprehensive recognition of its pathogenesis,there were not specific treatment on it.It is reported that the T-cell immunoglobulin and mucin-domain-containing molecule(Tim)of Tim-1 play critical role in sepsis inflammation,immune tolerance and apoptosis,which is relative specific factor in assessment of sepsis prognostic and treatment efficiency,indicating that it could be a novel target in sepsis as well as provide a novel direction.This article mainly stated the discovery,structure,distribution and immune effect of Tim-1 as well as the possible role of TIM-1in immunosuppression,lymphocyte proliferation and apoptosis,in order to provide reference for further research the treatment of sepsis.