银屑病角质形成细胞增殖机制的研究进展

Research progress on the proliferation mechanism of keratinocytes in psoriasis

银屑病的发病机制极其复杂,角质形成细胞(KCs)异常增殖是其重要的病理特征之一。在致病过程中,诸多因素可引起KCs增殖,且各因素间相互影响致使银屑病反复发作,难以治愈。本文从炎性细胞因子、氧化应激、微小RNA以及中医药拮抗KCs增殖等方面进行综述,为深入研究银屑病的发病机制及临床精准治疗提供参考。

Psoriasis is a common chronic inflammatory skin disease.Its pathogenesis is extremely complex.The abnormal proliferation of keratinocytes(KCs)is one of its important pathological features.In the process of pathopoiesis,many factors can cause proliferation of KCs,and the interaction of various factors leads to the recurrence of psoriasis,which is more difficult to cure.In this paper,we focus on inflammatory cytokines,oxidative stress,microRNA and traditional Chinese medicine antagonizing the proliferation of KCs,so as to provide reference for further study of pathogenesis and clinical precise treatment of psoriasis.