冠状病毒与眼部传染风险

Coronavirus and the risk of ocular transmission

冠状病毒是可感染人类的一类常见呼吸道病毒,已知其是通过飞沫和密切接触在人与人之间传播。近期在世界范围内流行的2019新型冠状病毒(2019-nCoV)已造成数以千万人感染,在部分临床确诊患者的结膜分泌物和泪液中发现了2019-nCoV。本文就冠状病毒在眼表传染的解剖基础、其受体在眼部的表达特征、临床前动物研究结果以及患者临床表现,对文献进行总结和分析,以探讨眼部作为传播途径的可能性,同时提出眼部防护的思考和建议,以供眼科医师在临床工作中参考。

Coronaviruses are a common class of respiratory viruses that can cause human infections.2019 novel coronavirus(2019-nCoV),a new coronavirus that has recently caused a pandemic,has affected millions of people and put tremendous pressure on the health systems of almost every country in the world.Coronaviruses are known to spread from person to person through droplets or contact.The 2019-nCoV has also been found in the conjunctival secretions and tears of some clinically diagnosed patients.To assess whether the eye is one of the transmission routes of the virus,we review literature,and summarize the anatomy of the eye-nose pathway,the expression of the virus receptor in the eye,the preclinical animal studies,and the clinical data.We analyze the possibility of eyes as a means of transmission and propose some suggestions of ocular protection.