普瑞巴林与加巴喷丁治疗带状疱疹后神经痛的效果比较

Comparison of the efficacy of pregabalin and gabapentin in the treatment of postherpetic neuralgia

目的比较普瑞巴林与加巴喷丁治疗带状疱疹后神经痛(PHN)的临床效果。方法选取2018年1月-2020年1月湖南省常德市第一人民医院收治的PHN患者82例,根据治疗方法的不同分为A组和B组各41例。A组口服普瑞巴林胶囊治疗,B组口服加巴喷丁胶囊治疗。比较2组临床疗效、治疗前后疼痛视觉模拟量表(VAS)评分及不良反应。结果 A组患者总有效率为85.37%,高于B组的60.98%(χ^(2)=6.212,P=0.013)。治疗后,2组患者VAS评分均低于治疗前,且A组低于B组(P<0.01)。A组患者不良反应总发生率为17.07%,低于B组的36.59%(χ^(2)=3.976,P=0.046)。结论普瑞巴林与加巴喷丁治疗PHN均有一定的效果,但普瑞巴林的镇痛疗效及安全性均优于加巴喷丁,值得临床推广。

Objective To compare the clinical effects of pregabalin and gabapentin in the treatment of post-herpetic neuralgia(PHN). Methods A selection of 82 patients with PHN admitted to the First People’ s Hospital of Changde City,Hunan Province from January 2018 to January 2020,according to the different treatment methods,they were divided into group A and group B with 41 cases each. Group A was treated with pregabalin capsules and group B was treated with gabapentin capsules. The clinical efficacy,visual analogue scale(VAS) scores of pain before and after treatment and adverse reactions were compared between the two groups. Results The total effective rate of patients in group A was 85. 37%,which was higher than 60. 98% in group B(χ^(2)= 6. 212,P = 0. 013). After treatment,the VAS scores of the two groups were lower than before treatment,and group A was lower than group B(P< 0. 01). The total incidence of adverse reactions in group A was 17. 07%,which was lower than 36. 59% in group B(χ^(2)= 3. 976,P = 0. 046). Conclusion Pregabalin and gabapentin have certain effects in the treatment of PHN,but the analgesic efficacy and safety of pregabalin are better than gabapentin,which is worthy of clinical promotion.