星蒌承气汤对脑梗死痰热腑实证患者IL-6表达疗效的临床观察

Clinical Observation on the Curative Effect of Tongfu Therapy on IL-6 Expression in Patients with Cerebral Infarction with Syndrome of Phlegm Heat

目的:研究分析星蒌承气汤对急性脑梗死痰热腑实证患者IL-6表达的临床疗效。方法:选取2017年1月至2018年12月于我院中医科住院的痰热腑实证急性脑梗死患者123例作为研究对象,先将患者随机分为观察组与对照组,其中观察组(合并SAI患者29例,未合并SAI患者53例)82例患者服用星蒌承气汤治疗,对照组(合并SAI患者21例,未合并SAI患者20例)41例患者口服杜密克治疗。分析比较治疗前合并及不合并SAI患者的IL-6表达情况,比较两组不同治疗方案对合并及不合并SAI患者的IL-6表达的影响情况;比较两组患者总体治疗疗效。结果:两组患者中合并SAI患者浓度水平呈下降趋势,且治疗前后差异具有统计学意义(P<0.05),观察组中合并SAI患者浓度水平下降幅度高于对照组中合并SAI患者,但差异无统计学意义(P>0.05)。两组患者中未合并SAI患者治疗后IL-6浓度水平明显高于治疗前IL-6浓度水平,差异无统计学意义(P>0.05),合并SAI患者治疗前后IL-6浓度水平均明显高于未合并SAI患者,差异具有统计学意义(P<0.05)。观察组的总有效率(71.95%)明显高于对照组总有效率(53.65%),差异具有统计学意义(P<0.05)。结论:经过治疗后,合并SAI患者IL-6浓度水平逐渐下降,未合并SAI患者IL-6浓度水平缓慢上升,但所有患者的IL-6浓度水平经过治疗后均趋向平稳;两种治疗方法中,中医通腑泻热疗法(星蒌承气汤治疗)更能改善患者IL-6的浓度水平以及急性脑梗死患者的症状与体征。

Objective:To study and analyze the clinical effect of Tongfu therapy on IL-6 expression in patients with acute cerebral infarction.Methods:Selected 123 patients with acute cerebral infarction with phlegm-heat fu organs who were hospitalized in the Department of Traditional Chinese Medicine of our hospital from January 2017 to December 2018 as the research objects.First,the patients were randomly divided into observation group and control group.Among them,the observation group(29 patients with SAI and 53 patients without SAI)82 patients were treated with Xinglou Chengqi Decoction,and 41 patients in the control group(21 patients with SAI and 20 patients without SAI)were treated with Dumic orally.Analyze and compare the expression of IL-6 in patients with and without SAI before treatment,compare the effects of different treatment options in the two groups on the expression of IL-6 in patients with and without SAI;compare the overall therapeutic efficacy of the two groups.Results:The concentration level of patients with SAI in the two groups showed a downward trend,and the difference before and after treatment was statistically significant(P<0.05).The concentration level of patients with SAI in the observation group decreased more than that in the control group,but there was no statistical significance(P>0.05).In the two groups of patients,the IL-6 concentration level of patients without SAI after treatment was significantly higher than that before treatment,and the difference was not statistically significant(P>0.05).The IL-6 concentration levels of patients with SAI before and after treatment were significantly higher than patients without SAI,the difference was statistically significant(P<0.05).The total effective rate of the observation group(71.95%)was significantly higher than the total effective rate of the control group(53.65%),and the difference was statistically significant(P<0.05).Conclusion:After treatment,the IL-6 concentration level of patients with SAI gradually decreased,and the IL-6 concentration level of patients without SAI increased slowly,but the IL-6 concentration level of all patients became stable after treatment;in the two treatment methods,TCM Tongfu Xiere Therapy(Xinglou Chengqi Decoction)can improve the concentration level of IL-6 in patients and the symptoms and signs of patients with acute cerebral infarction.