HIV感染者/AIDS患者服药依从性管理的系统评价再评价

Effectiveness of management of medication compliance to antiretroviral therapy in HIV/AIDS patients:an overview of reviews

目的对接受抗病毒治疗(antiretroviral therapy,ART)的HIV感染者/AIDS患者服药依从性管理的系统评价进行再评价。方法2020年8月,计算机检索中国知网、中国生物医学文献数据库以及乔安娜布里格斯研究所、The Cochrane Library等数据库,检索HIV感染者/AIDS患者ART服药依从性管理的系统评价,由2名研究成员独立进行文献筛选、资料提取,分别对纳入的系统评价和结局指标进行质量评价。结果共纳入16篇系统评价,评价结果显示,12篇质量等级为极低,4篇质量等级为低。结果显示,移动技术干预方法能提高HIV感染者/AIDS患者的服药依从性,服药依从性的评价方法多元。结论移动技术可提高HIV感染者/AIDS患者的服药依从性,但现存的证据不足,HIV感染者/AIDS患者ART服药依从性管理的总体效果需进一步探讨,后续仍需要高质量、大样本的研究来进一步验证。

Objective To overview the systematic reviews of effectiveness of management of medication compliance to antiretroviral therapy(ART)in HIV/AIDS patients.Methods CNKI,CBM,JBI,The Cochrane Library,databases were searched to identify the relevant systematic reviews.2 researchers screened systematic reviews and extracted the data independently.AMSTAR 2 scale and GRADE system were used to assess the quality of included systematic reviews.Results A total of 16 systematic reviews were included in this study.Results showed that the quality of 12 systematic reviews were rated as very low,and the quality of 4 systematic reviews were rated as low.The application of mobile technology can improve medication adherence of HIV/AIDS patients,and the evaluation methods of medication adherence are diverse.Conclusion The application of mobile technology can improve medication adherence of HIV/AIDS patients.However,existing studies are insufficient.The overall effectiveness of management of medication compliance to ART in HIV/AIDS patients needs to be further explored and validated by subsequent high-quality and large-sample studies.