2019年深圳市南山区495名孕妇百日咳、白喉、破伤风抗体水平调查

Survey of antibody levels of pertussis,diphtheria and tetanus in 495 pregnant women in Nanshan District of 2019,Shenzhen

目的了解深圳市南山区孕妇百日咳、白喉、破伤风IgG抗体水平。方法于2019年1—3月,以深圳市南山区某医院495名孕妇作为调查对象,采用酶联免疫吸附试验法检测血清中百日咳、白喉、破伤风IgG抗体水平,比较不同特征孕妇各抗体水平差异。结果孕妇年龄为(29.23±4.08)岁。百日咳的抗体几何平均浓度(GMC)M(P_(25),P_(75))为2.589(1.172,4.953)IU/ml,1.01%(5名)的孕妇百日咳抗体浓度≥40 IU/ml,75.15%(372名)的孕妇百日咳抗体浓度<5 IU/ml。孕妇白喉GMC值和抗体阳性率分别为0.024(0.009,0.065)IU/ml、72.53%(359名),破伤风GMC值和抗体阳性率分别为0.014(0.006,0.034)IU/ml、53.74%(266名);不同特征孕妇白喉、破伤风抗体水平以及抗体阳性率差异均无统计学意义。结论深圳市南山区孕妇百日咳、白喉、破伤风抗体浓度均处于较低水平,不足以保护自身免受疾病的感染。

Objective The purpose of this study was to investigate the IgG antibody levels of whooping cough,diphtheria,and tetanus in pregnant women in Nanshan District.Methods From January to March 2019,495 pregnant women who met the inclusion criteria in a hospital in Nanshan District,Shenzhen were selected as the survey subjects.The enzyme-linked immunosorbent assay was used to detect serum levels of pertussis,diphtheria,and tetanus IgG antibodies and we compared the differences in antibody levels of pregnant women with different characteristics.Results The maternal age was(29.23±4.08)years old.The geometric mean concentration of pertussis antibody was 2.589(1.172-4.953)IU/ml,1.01%(5 cases)of pregnant women had pertussis antibody concentration≥40 IU/ml,and 75.15%(372 cases)of pregnant women had pertussis antibody concentration<5 IU/ml.The GMC value and antibody positive rate of diphtheria in pregnant women were 0.024(0.009-0.065)IU/ml and 72.53%(359 cases),respectively.The GMC value and antibody positive rate of tetanus in pregnant women were 0.014(0.006-0.034)IU/ml and 53.74%(266 cases),respectively.There was no statistical difference in the antibody level and antibody positive rate among pregnant women of diphtheria and tetanus,respectively.Conclusion The concentration of antibodies against pertussis,diphtheria,and tetanus in pregnant women are all at a low level,which is not enough to protect themselves from disease infection.