正念干预卒中后抑郁症状的meta分析

Mindfulness Training on Post-stroke Depression:A Meta Analysis

目的评价正念训练干预改善卒中后抑郁的疗效。方法计算机检索Cochrane Library、PubMed、Embase、BMJ、中国知网、维普网、万方数据库从建库至2021年1月20日公开发表的关于正念治疗卒中后抑郁疗效的随机对照试验(randomized controlled trial,RCT)。结局指标使用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)或者抑郁自评量表(selfrating depression scale,SDS)对干预组和对照组进行评估。对符合纳排标准的文献用RevMan 5.3软件进行数据分析。结果共纳入10项RCT研究,594例患者。meta分析结果显示,干预组患者干预后的HAMD评分[加权均数差(weighted mean difference,WMD)-4.06,95%CI-4.70~-3.42,P<0.00001]及SDS评分(WMD-6.32,95%CI-7.75~-4.90,P<0.00001)均较对照组降低。结论正念训练结合常规护理及治疗更有利于卒中后抑郁症状的缓解。

Objective To evaluate the efficacy of mindfulness training on post-stroke depression.Methods The published randomized controlled trials(RCTs)of mindfulness for post-stroke depression were searched in scientific databases[Cochrane Library,PubMed,Embase,British Medical Journal(BMJ),China National Knowledge Infrastructure(CNKI),Chinese science and technology data and Wanfang Data]from inception to January 20,2021.The efficacy of mindfulness training was analyzed,and the outcome indicators were evaluated by Hamilton depression scale(HAMD)or self-rating depression scale.The data of eligible RCTs were analyzed using RevMan 5.3.Results A total of 10 RCTs were included.The HAMD score[weighted mean difference(WMD-4.06,95%CI-4.70--3.42,P<0.00001)and SDS score(WMD-6.32,95%CI-7.75--4.90,P<0.00001)]in intervention group were lower than that in control group.Conclusions Mindfulness training with conventional treatment can further improve the symptoms of post-stroke depression.