南充地区汉族健康人群血清胃蛋白酶原和胃泌素-17参考区间调查研究

Investigation on the reference interval of serum pepsinogen and gastrin-17 in healthy Han people in Nanchong area

目的建立南充地区汉族健康人群血清胃蛋白酶原(PG)和胃泌素-17(G-17)的参考区间。方法选取2019年1-8月在该院进行血清PG和G-17检测的3 444例汉族健康体检者作为研究对象,分析不同性别、年龄人群血清PG和G-17水平的差异,建立血清PG和G-17的参考区间。结果 3 444例汉族健康人群血清PGⅠ、PGⅡ、PGⅠ/PGⅡ和G-17的中位水平分别为94.21μg/L、9.29μg/L、12.26、2.57pmol/L。男性汉族健康人群血清PGⅠ、PGⅡ水平均明显高于女性,差异均有统计学意义(P<0.05)。男、女汉族健康人群中,各年龄段血清PGⅠ、PGⅡ水平差异均有统计学意义(P<0.05),各年龄段血清PGⅠ/PGⅡ、G-17水平差异均无统计学意义(P>0.05)。男性血清PGⅠ参考区间:21~40岁为33.34~170.95μg/L,>40~60岁为39.73~181.77μg/L,>60岁为45.85~194.35μg/L;女性血清PGⅠ参考区间:20~50岁为26.66~164.06μg/L,>50~60岁为27.25~172.96μg/L,>60岁为30.84~186.97μg/L。男性血清PGⅡ参考区间:21~40岁为3.56~17.64μg/L,>40~60岁为4.45~19.05μg/L,>60岁为5.64~21.40μg/L;女性血清PGⅡ参考区间:20~50岁为3.17~16.40μg/L,>50~60岁为3.82~18.28μg/L,>60岁为4.25~20.69μg/L。血清PGⅠ/PGⅡ参考区间为6.36~22.65。血清G-17参考区间为1.04~7.05pmol/L。结论南充地区男、女汉族健康人群血清PGI、PGⅡ水平存在差异,通过建立PG和G-17的参考区间,可为临床研究提供数据支撑。

Objective To establish the reference interval of serum pepsinogen(PG)and gastrin-17(G-17)in healthy Han people in Nanchong area.Methods Selected 3444 cases of healthy Han people who underwent serum PG and G-17 detection in the hospital from January to August 2019 as the research objects.Analyzed the differences in serum PG and G-17 levels among people of different genders and ages,and established the reference interval for serum PG and G-17.Results The median levels of serum PGⅠ,PGⅡ,PGⅠ/PGⅡand G-17 in 3444 healthy Han people were 94.21μg/L,9.29μg/L,12.26 and 2.57 pmol/L respectively.Serum PGⅠand PGⅡlevels of healthy male Han people were significantly higher than those of females,and the differences were statistically significant(P<0.05).In the healthy male and female Han people,the differences in serum PGⅠand PGⅡlevels in all age groups were statistically significant(P<0.05),and the differences in serum PGⅠ/PGⅡand G-17 levels in all age groups were not statistically significant(P>0.05).Male serum PGⅠreference range:21-40 years old was 33.34-170.95μg/L,>40-60 years old was 39.73-181.77μg/L,>60 years old was 45.85-194.35μg/L.Female serum PGⅠreference range:20-50 years old was 26.66-164.06μg/L,>50~60 years old was 27.25-172.96μg/L,>60 years old was 30.84-186.97μg/L.Male serum PGⅡreference range:21-40 years old was 3.56-17.64μg/L,>40-60 years old was 4.45-19.05μg/L,>60 years old was 5.64-21.40μg/L.Female serum PGⅡreference range:20-50 years old was 3.17-16.40μg/L,>50~60 years old was 3.82-18.28μg/L,>60 years old was 4.25-20.69μg/L.The reference interval of serum PGⅠ/PGⅡwas 6.36-22.65,and the reference interval of serum G-17 was 1.04-7.05 pmol/L.Conclusion There are differences in the levels of PGⅠand PGⅡbetween health male and female Han people in Nanchong area.The establishment of reference intervals for serum PG and G-17 can provide data support for clinical research.