儿童食物蛋白诱导的肠病

Food protein-induced enteropathy in children

食物蛋白诱导的肠病(FPE)是以间断呕吐和肠吸收不良综合征为特征的食物过敏性相关性消化道疾病,绝大多数为非Ig E介导。常见的过敏原有牛奶、大豆等。诊断标准为:初次诊断时<9个月;主要症状是呕吐和发育不良。有症状的儿童小肠活检证实诊断,显示绒毛损伤、隐窝增生和炎症。虽然绒毛损伤的完全愈合需要几个月的时间,但症状在去除过敏食物数周内缓解。排除其他疾病。主要治疗方法是回避可疑食物,选择合适的营养替代品。

Food protein-induced enteropathy(FPE)is a food allergy-related gastrointestinal disease characterized by intermittent vomiting and intestinal malabsorption syndrome,most of which are non-IgE mediated.Common allergens are milk,soybean,etc.The diagnostic criteria are being less than 9 months at the first diagnosis,and the main symptoms are vomiting and dysplasia.The diagnosis is confirmed by small intestinal biopsy in symptomatic children,showing villous lesions,crypt hyperplasia and inflammation.Although it takes several months for the villus injury to heal completely,the symptoms are relieved within a few weeks after the allergic food is removed.Other diseases are excluded.The main treatment is to avoid suspicious food and choose appropriate nutritional substitutes.