复方愈创木酚磺酸钾口服液治疗小儿急性支气管炎的效果

Effects of Compound Guaiacol Potassium Sulfonate Oral Solution on acute bronchitis in children

目的探究复方愈创木酚磺酸钾口服液治疗小儿急性支气管炎的效果。方法选取2019年1月~2020年1月荆州市第三人民医院收治的84例急性支气管炎患儿作为研究对象,按照随机数字表法将其分为对照组和观察组,每组各42例。对照组给予利巴韦林注射液静脉滴注,观察组在此基础上予以复方愈创木酚磺酸钾口服液口服。治疗10 d后,比较两组疗效、临床总有效率、各临床症状消失时间、药物不良反应总发生率和治疗前及治疗10 d后两组血清炎症指标[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)]水平。结果治疗10 d后,观察组疗效优于对照组,临床总有效率高于对照组,差异有统计学意义(P<0.05);观察组咳嗽、高热、咯痰及肺部啰音消失时间短于对照组,差异有统计学意义(P<0.05);两组胃肠道反应、头晕、嗜睡药物等不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗前,两组血清CRP、IL-6、TNF-α比较,差异无统计学意义(P>0.05);治疗10 d后,两组CRP、IL-6、TNF-α低于治疗前,观察组血清CRP、IL-6、TNF-α低于对照组,差异有统计学意义(P<0.05)。结论复方愈创木酚磺酸钾口服液辅助治疗小儿急性支气管炎在加快患儿临床症状消失,改善炎症因子相关指标方面,安全可靠且效果显著,具有临床应用价值。

Objective To investigate the effect of Compound Guaiacol Potassium Sulfonate Oral Solution on children with acute bronchitis.Methods A total of 84 children with acute bronchitis treated in the Third People′s Hospital of Jingzhou City from January 2019 to January 2020 were selected as the research subjects.According to random number table method,they were divided into control group and observation group,with 42 cases in each group.The control group was given Ribavirin Injection intravenously,and the observation group was given Compound Guaiacol Potassium Sulfonate Oral Solution on this basis.After 10 d of treatment,the differences in efficacy,time of disappearance of clinical symptoms and incidence of adverse drug reactions,as well as the differences in serum inflammatory indexes(C-reactive protein[CRP],interlenkin-6[IL-6]and tumor necrosis factor[TNF]-α)between the two groups before and after 10 d of treatment were compared.Results After 10 d of treatment,the efficacy in the observation group was better than that in control group,and the total clinical effective rate was higher than that in the control group,and the differences were statistically significant(P<0.05).The disappearance times of cough,high fever,expectoration and lung rales in the observation group were shorter than those in control group(P<0.05).There was no significant difference in the total incidence rate of adverse drug reactions of gastrointestinal reactions,dizziness and somnolence between the two groups(P>0.05).Before treatment,there were no significant differences in serum CRP,IL-6 and TNF-αbetween the two groups(P>0.05).After 10 d of treatment,CRP,IL-6 and TNF-αin the two groups were lower than those before treatment,and serum CRP,IL-6 and TNF-αin observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Compound Guaiacol Potassium Sulfonate Oral Solution in the adjuvant treatment of children with acute bronchitis is safe,reliable and effective in accelerating the disappearance of clinical symptoms and improving the related indicators of inflammatory factors,which has clinical application value.