摘要
缺血性卒中是一类具有高发病率、高死亡率和高致残率的脑血管病,给社会带来巨大的医疗负担。长链非编码RNA(long non-coding RNA,lncRNA)H19与缺血性卒中后的氧化应激、炎症反应、细胞凋亡、自噬以及神经发生等病理生理学机制有着密切的联系,近年来受到广泛关注。文章对lncRNA H19参与缺血性卒中的病理生理学机制进行了综述,以期为缺血性卒中的诊断及治疗提供新的思路。
Ischemic stroke is a type of cerebrovascular disease with high morbidity,high mortality and high disability,which brings a huge medical burden to the society.Long non-coding RNA(lncRNA)H19 is closely associated with the pathophysiological mechanisms such as oxidative stress,inflammation,apoptosis,autophagy,and neurogenesis after ischemic stroke.It has received widespread attention in recent years.This article reviews the pathophysiological mechanism of lncRNA H19 in ischemic stroke,in order to provide new ideas for the diagnosis and treatment of ischemic stroke.
作者
钟丽媛
范俊芬
罗玉敏
Zhong Liyuan;Fan Junfen;Luo Yumin(Institute of Cerebrovascular Disease,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Department of Neurology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China)
出处
《国际脑血管病杂志》
2021年第2期120-125,共6页
International Journal of Cerebrovascular Diseases
基金
国家自然科学基金 (81771413)
北京市教育委员会科技计划项目 (KM201910025019)
首都卫生发展科研专项 (首发2020-2-1032)
国家自然科学基金青年基金 (82001268)。
