微流控技术制备纳米制剂的研究与应用前景

Recent Advances and Application Prospects of Microfluidic Technology for Preparation of Nanoformulations

微流控技术为可控可重复地制备纳米药物递送系统提供了新的连续化生产平台。微流控技术的纳米颗粒具有一步成型、可设计的流道结构、可控可调的工艺参数和可高通量放大生产等优势,有助于克服常规纳米制剂制备方法批间差异大、放大生产难的局限,开发出可控可重现的工业生产线,推进纳米制剂的临床应用。本文综述了微流控技术用于纳米制剂制备的作用机制、微混合结构设计及应用优势,以期为微流控技术的进一步工业化应用提供参考。

Microfluidic technology provides a new continuous fabrication system to develop highly controllable and reproducible preparation of nano-drug delivery systems.The one-step formation of nanoparticles,designable channel structures,controllable process parameters and highly throughput production,all above might be solutions to the challenges(high batch-to-batch variability,small scale production,and so on)through conventional preparation methods.Microfluidic technology offers a promise approach to accelerate the clinical translation of nanoformulations.This review emphasizes on the action mechanism,flow patterns of microfluidics,structures of micromixers and application advantages of microfluidic technology for the production of nano-drug delivery systems,expecting to provide some references for the further industrial application of microfluidics.