摘要
天然产物是药物发现的宝库。从天然产物中分离得到的多酚类化合物因含有大量羟基,使其具有抗氧化、抗肿瘤和抗病毒等多种生物活性,目前已成为研究热点之一。本文以多酚类化合物不同的生物活性为依据,对天然产物中存在的多酚类化合物进行了分类和总结,为后续基于生物活性的多酚类药物,特别是抗病毒药物的研究提供参考。
Natural products are a storehouse for drug discovery.Polyphenols isolated from natural products exhibit a variety of biological activities such as anti-oxidation,antitumor and antiviral activity,etc.as they have multiple hydroxyl groups.Based on the different biological activities of polyphenols,this review summarizes the polyphenols present in natural products and provides reference value for the subsequent research on bioactive polyphenols,especially antiviral activity of polyphenols.
作者
刘昕皓
魏粉菊
王学顺
展鹏
刘新泳
LIU Xinhao;WEI Fenju;WANG Xueshun;ZHAN Peng;LIU Xinyong(Dept.of Medicinal Chemistry,School of Pharmaceutical Sciences,Shandong University,Jinan 250012)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2021年第4期471-483,共13页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金资助项目(81420108027,81573347)
山东省重点研发计划(2017CXGC1401,2019JZZY021011)。