糖耐量异常患者的红细胞体积分布宽度与代谢综合征的相关性

The relationship between red blood cell distribution width and metabolic syndrome in patients with impaired glucose tolerance

目的研究糖耐量异常患者的红细胞体积分布宽度(RDW)与代谢综合征(MS)的相关性。方法选取2015年10月至2019年9月在长沙市中医医院(长沙市第八医院)采用口服葡萄糖耐量试验筛查糖耐量异常患者共415例,进行一般资料收集,检测血常规、生化等指标。符合代谢综合征诊断标准者为观察组193例,余为对照组222例。比较两组RDW及其他临床指标差异,分析RDW与其他指标相关性,分析代谢综合征的危险因素。结果⑴观察组RDW、收缩压、舒张压、身高(Ht)、体重(Wt)、腰围(Wc)、TG、CHOL、LDL、Cr、UA、ALT、hs-CRP、BMI均显著高于对照组,HDL显著低于对照组,差异有统计学意义(P<0.05);⑵相关分析显示RDW与收缩压、舒张压、Ht、Wt、Wc、TG、CHOL、Cr、UA、ALT、hs-CRP、BMI呈正相关,与HDL呈负相关(P<0.05);⑶二元logistic回归分析显示RDW、Wt、Wc、CHOL、HDL、LDL、hs-CRP为糖耐量异常患者MS的独立危险因素。结论RDW升高是糖耐量异常人群发生代谢综合征的预测因子,可能为代谢综合征的防治提供一定的参考价值。

Objective To evaluate the relationship between red blood cell distribution width(RDW)and metabolic syndrome(MS)in patients with impaired glucose tolerance(IGT).Methods A total of 415 patients with abnormal glucose tolerance were screened by oral glucose tolerance test in Changsha Traditional Chinese Medicine Hospital(Changsha Eighth Hospital)from October 2015 to September 2019.General data were collected and blood routine and biochemical indexes were detected.There were 193 cases in the observation group and 222 cases in the control group.The RDW and other clinical indicators were compared between the two groups,the correlation between RDW and other indicators was analyzed,and the risk factors of metabolic syndrome were analyzed.Results⑴The RDW,systolic blood pressure(SBP),diastolic blood pressure(DBP),height(Ht),weight(Wt),waist circumferenc(Wc),triglyceride(TG),cholesterol(CHOL),low density lipoprotein(LDL),creatinine(Cr),uric acid(UA),alanine aminotransferase(ALT),high sensitive C-reactive protein(hs-CRP),body mass index(BMI)of the observation group were significantly higher than those of the control group,while the high density lipoprotein(HDL)was significantly lower than that of the control group,with statistically significant difference(P<0.05);⑵correlation analysis showed that RDW was positively correlated with SBP,DBP,Ht,Wt,Wc,TG,CHOL,Cr,UA,ALT,hs-CRP,BMI,and negatively correlated with HDL(P<0.05);⑶binary logistic regression analysis showed that RDW,Wt,Wc,CHOL,HDL,LDL and hs-CRP were independent risk factors for MS in patients with impaired glucose tolerance.Conclusions The increase of RDW is a predictor of metabolic syndrome in people with abnormal glucose tolerance,which may provide some reference value for the prevention and treatment of metabolic syndrome.