肺源性心脏病呼吸衰竭患者血清GGT CysC hs-CRP水平与其预后的关系

The Relationship Between Serum GGT CysC and Hs-CRP Levels and Prognosis in Patients with Corpulmonale Complicated by Respiratory Failure

目的:探讨肺源性心脏病呼吸衰竭患者血清γ-谷氨酰转肽酶(γ-glutamyl transpeptidase,GGT)、胱抑素C(cystatin C,CysC)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与其预后的关系。方法:选择2017年2月至2020年1月我院收治的95例肺源性心脏病呼吸衰竭患者为研究对象(观察组),另选择同期于本院进行体检的50例健康体检者为对照组,均检测其血清GGT、CysC和hs-CRP水平,对比两组血清GGT、CysC和hs-CRP水平。根据肺源性心脏病呼吸衰竭患者住院期间和出院后24h内是否死亡将之分为存活组和死亡组,采用多因素Logistic回归分析影响肺源性心脏病呼吸衰竭患者预后的相关因素。结果:观察组血清GGT、CysC和hs-CRP水平均高于对照组(P<0.05);死亡组血清GGT、CysC和hs-CRP水平均高于存活组(P<0.05);GGT、CysC和hs-CRP是肺源性心脏病呼吸衰竭患者死亡的影响因素(P<0.05)。结论:肺源性心脏病呼吸衰竭患者血清GGT、CysC和hs-CRP水平较高,且与患者预后存在相关性,临床可通过监测患者血清GGT、CysC和hs-CRP水平评估其预后。

Objective:To investigate the relationship between serumγ-glutamyl transpeptidase(GGT),cystatin C(CysC)and high-sensitivity C-reactive protein(hs-CRP)levels and prognosis in patients with corpulmonale complicated by respiratory failure.Methods:95 patients with corpulmonale complicated by respiratory failure(observation group)treated in the hospital between February 2017 and January 2020,and 50 healthy subjects(control group)received physical examination in this hospital during the same period were enrolled in this study.Serum GGT,CysC and hs-CRP levels in the two groups were detected and compared.According to the condition during hospitalization and within 24 hours after discharge,the patients were divided into survival group and death group.Multivariate logistic regression analysis of relevant factors affecting the patients’prognosis was performed.Results:Serum GGT,CysC and hs-CRP levels in the observation group were higher than those in the control group(P<0.05).Serum GGT,CysC and hs-CRP levels were higher in the death group than in the survival group(P<0.05).Serum GGT,CysC and hs-CRP were influencing factors of death in patients with corpulmonale complicated by respiratory failure(P<0.05).Conclusion:Serum GGT,CysC and hs-CRP levels in patients with corpulmonale complicated by respiratory failure are relatively higher,which are correlated with the prognosis.Clinically,the prognosis can be assessed by monitoring serum GGT,CysC and hs-CRP levels in patients.