血液透析分别联合血液透析滤过和血液灌流对患者肾性贫血的影响

Effect of Hemodialysis Combined with Hemodiafiltration and Hemoperfusion on Renal Anemia in Patients

目的:探究血液透析分别联合血液透析滤过和血液灌流对患者肾性贫血的影响。方法:选择2018年8月至2020年4月于我院行维持性血液透析治疗的患者100例,根据简单随机数字法分为A组(血液透析联合血液透析滤过)和B组(血液透析联合血液灌流),各50例。比较两组治疗前后肾性贫血指标[血红蛋白(Hb)、红细胞压积(Hct)、网织红细胞百分比(Ret)、血清铁]与血钙、血磷、甲状旁腺激素(iPTH)水平,并统计两组不良反应发生率。结果:治疗后B组Hb、Hct、Ret、血清铁水平均显著高于A组,差异有统计学意义(P<0.05);治疗后B组血钙水平显著高于A组,血磷及iPTH显著低于A组,差异有统计学意义(P<0.05);B组不良反应发生率显著低于A组,差异有统计学意义(P<0.05)。结论:较血液透析联合血液透析滤过,血液透析联合血液灌流可更加有效纠正患者肾性贫血,降低iPTH水平,改善钙磷代谢。

Objective:To explore the effect of hemodialysis combined with hemodiafiltration and hemoperfusion on renal anemia in patients.Methods:100 patients who underwent maintenance hemodialysis in our hospital from August 2018 to April 2020 were selected.According to the simple random number method,they were divided into group A(hemodialysis combined with hemodiafiltration)and group B(hemodialysis combined with hemoperfusion),with 50 cases in each group.The renal anemia indicators[hemoglobin(Hb),hematocrit(Hct),reticulocyte percentage(Ret),serum iron]and blood calcium,blood phosphorus and parathyroid hormone(iPTH)were compared between the two groups before and after treatment,and the incidence rate of adverse events was counted in the two groups.Results:After treatment,Hb,Hct,Ret and serum iron were significantly higher than those in group A(P<0.05).After treatment,the blood calcium level in group B was significantly higher than that in group A while the levels of blood phosphorus and iPTH were significantly lower than those in group A(P<0.05).The incidence rate of adverse reactions in group B was significantly lower than that in group A(P<0.05).Conclusion:Compared with hemodialysis combined with hemodiafiltration can more effectively correct renal anemia,reduce iPTH level and improve calcium and phosphorus metabolism in patients with maintenance hemodialysis.