外周静脉血肿瘤异常蛋白检测对乳腺癌患者的疗效监测及评估价值

Monitoring and Evaluating Value of Tumor Abnormal Protein Detection in Peripheral Venous Blood of Patients with Breast Cancer

[目的]探讨外周静脉血肿瘤异常蛋白(TAP)检测对乳腺癌患者的疗效监测及评估效能。[方法]选取本院收治的80例女性乳腺癌患者(乳腺癌组)和同期在本院进行体检的68例健康女性志愿者(对照组),对比乳腺癌组和对照组外周静脉血TAP水平;依据化疗效果将患者分为有效组和无效组,对比有效组和无效组乳腺癌患者的临床资料.采用Logistie回归分析法分析乳腺癌患者治疗效果的影响因素;采用受试者工作特征曲线(ROC)分析外周静脉血TAP对乳腺癌患者治疗效果的评估价值。[结果]乳腺癌组治疗前TAP水平高于对照组,且差异有显著性(P<0.05);乳腺癌患者化疗总有效率为48.75%(39/80);无效组临床分期Ⅲ、低分化、有淋巴结转移、雌激素受体阳性、孕激素受体构成比及治疗后TAP水平高于有效组,且差异有显著性(P<0.05).无效组TAP下降率低于有效组(P<0.05);Logistic回归分析结果显示:临床分期、分化程度、淋巴结转移、TAP下降率均是影响乳腺癌患者治疗效果的影响因素(P<0.05);ROC分析显示:TAP评估乳腺癌患者治疗效果的最佳截断点为15.59%,灵敏度为73.17%,特异度为82.05%,曲线下面积(AUC)值为0.811。[结论]乳腺癌患者中外周静脉血TAP异常偏高,且乳腺癌患者治疗前后TAP水平变化与其治疗效果有关,其可用于对乳腺癌患者的疗效监测及评估。

[Objective]To explore the eficacy monitoring and evaluation of tumor abnormal protein(TAP)in periph-eral venous blood in patients with breast cancer,[Methods]A total of 80 cases of female brcast cancer patients(the breast cancer group)admitted to the hospital and 68 healthy fermale volunteers(the control group)who underwent physical ex-amination in our hospital at the same time period were selected for the study.The TAP levels between the breast cancer group and the control group were compared.According to the efct of chemnotherapy,breast cancer patients were further divided into the ffective group and the inffective group.The elinical data of efective group and ineffective group were compared.Logistice regression analysis was used to analyze the influencing factors on the therapeutic efficacy of breast cancer patients.Receiver operating characteristic curve(ROC)was used to analyzed the evaluation value of tap in periph-eral venous blood for the treatment ffct of breast cancer patients.[Results]The TAP level of breast cancer group before treatment was higher than that of the control group(P<0.05).The total eftive rate of chemotherapy for breast canc-er patients was 48.75%(39/80).Compared to the eective group,patients in the inffective group has higher proportion of clinical staging,poor differentiation.lymph node metastasis,estrogen receptor,progesterone receptor composition ratio and higher TAP level after treatment(P<0.05).The TAP decline rate in the ineffective group was lower than that in the efctive group,the difference was statistically significant(P<0.05).Logistic regression analysis results showed that clinical stage,degree of differentiation,lymph node metastasis and TAP decline rate were the influencing factors in the treatment efeet of breast cancer patients(P<0.05).ROC analysis showed that the optimal cut off point for TAP to evaluate the treatment efect of breast cancer patients was 15.59%,with a sensitivity of 73.17%,a specificity of 82.05%,and an AUC value of 0.811.[Conclusion]TAP level in the peripheral venous blood is abnormally high in breast cancer pa-tients,and the change of TAP levels before and after treatment is closely related to the treatment effect of breast cancer patients,so it can be used to monitor and evaluate the efficacy of breast cancer patients.