子痫前期孕产妇血清补体相关因子与抗心磷脂抗体水平及其临床意义

Significance of Complement-related Factors and Anticardiolipin Antibody Detection in Pregnant Women with Preeclampsia

[目的]探讨子痫前期孕产妇血清补体相关因子及抗心磷脂抗体水平及其临床意义。[方法]回顾性分析2016年12月至2018年3月于本院分娩66例子痫前期患者(轻度子痫前期组)和54例重度子痫前期.患者(重度子痫前期组)的临床资料。选取同时期产检的正常产妇36例作为对照组。检测所有受试者血清中.补体因子D(CFD)以及脂联素(ADPN)、抗心磷脂抗体(ACA)水平。比较各因子表达水平与子痫病情的关系。[结果]重度子痫前期组CFD水平明显高于对照组与轻度子痫前期组,ADPN水平明显低于其他两组(P<0.05)。重度子痫前期组ACA-IgA.ACA-IgG与ACA-IgM均明显高于对照组,而ACA-IgA、ACA-IgG水平又明显高于轻度子痫前期组(P<0.05)。[结论]与正常妊娠期孕妇相比,子痫前期产妇机体CFD处于高水平状态,血清ACA-IgA、ACA-IgG与ACA-IgM表达均明显高于正常,且与病情严重程度成正比,而ADPN处于低水平状态,且随者病情严重程度成反比。

[Objective]To analyze the levels and significance of maternal complement related factors and anti-cardiolipin antibodies in preeclampsia.[Methods]The clinical data of 66 patients with preeclampsia(pre-eclampsia group)and 54 patients with severe preeclampsia(severe preeclampsia group)who gave birth in our hospital from December 2016 to March 2018 were selected for retrospective analysis.Thirty-six normal women at the same time were selected as the control group.Placental tissue,serum complement factor D(CFD),adi-ponectin(ADPN)levels,and serum anticardiolipin antibody(ACA)levels were measured in all maternal women.The expression levels of each factor in the 1wo groups were compared.[Results]The levels of CFD in severe preeclampsia were significantly higher than those in the control group and preeclampsia.The ADPN lev-el was significantly lower than the other two groups(P<0.05).The levels of ACA-IgA,ACA-IgG and ACA-IgM in severe preeclampsia were significantly higher than those in the control group.The levels of ACA-IgA and ACA-IgG in severe preclampsia were significantly higher than those in preclampsia(P<0.05).[Conclusion]Compared with normal pregnant women,the pre eclampsia maternal body CFD is at a high lev-el,serum ACA-IgA.ACA-IgG and ACA-lgM expression are significantly higher than normal,and is propor-tional to the severity of the disease.while ADPN is at Low level state,and inversely proportional to the severi-ty of the disease.