特应性皮炎与系统性疾病相关性的研究进展

Associations between atopic dermatitis and systemic diseases

特应性皮炎(AD)与其他过敏性疾病、自身免疫性疾病、感染性疾病、心血管疾病及精神障碍性疾病等系统性疾病关系密切且机制复杂。AD被认为是过敏进程的起点,也会影响多种过敏性疾病如食物过敏、过敏性鼻炎以及过敏性哮喘等的发生。AD与多种自身免疫性疾病的发生相关,也与某些恶性肿瘤发生率的降低及血清低维生素D水平有关。AD不仅是多器官感染和骨质疏松的潜在危险因素,还会增加患者发生心血管疾病、肾病综合征和皮肤干燥症的风险。此外,焦虑、抑郁等精神障碍性疾病也是AD的常见并发症。认识并加强AD与系统性疾病的相关研究,对改善AD患者预后和提高其生活质量有重要意义。

Atopic dermatitis(AD)is closely related to many systemic diseases,such as other allergic diseases,autoimmune diseases,infectious diseases,cardiovascular diseases and mental disorders,and the underlying mechanism is very complex.AD is considered to be a starting point of the allergy march,and affects the occurrence of various allergic diseases such as food allergies,allergic rhinitis and allergic asthma.AD is associated with the occurrence of many autoimmune diseases,decreased incidence of some malignant tumors and low serum levels of vitamin D.AD is not only a potential risk factor for multiple organ infections and osteoporosis,but also increases the risk of cardiovascular diseases,nephrotic syndrome,and skin dryness.In addition,mental disorders such as anxiety and depression are also common complications of AD.To recognize and investigate into the associations between AD and systemic diseases is of great significance for improving the prognosis and quality of life of AD patients.