早期食管癌和癌前病变内镜黏膜下剥离术后食管狭窄的预防研究进展

Progress in Prevention of Esophageal Stenosis after Endoscopic Submuco-sal Dissection for Early Esophageal Cancer and Precancerous Lesions

食管癌是起源于食管黏膜上皮的恶性肿瘤,是临床常见的恶性肿瘤之一。早期食管癌及癌病变经内镜下微创治疗即可根治,可取得与外科手术相当的疗效,且具有更高的手术安全性及术后生活质量。内镜黏膜下剥离术(endoscopic submucosal dissection, ESD)是最常采用的一种内镜微创技术,具有多种优势,但仍存在一定的并发症发生率。其中,术后食管狭窄为最常见的并发症,造成患者吞咽困难,严重影响患者的生活质量。随着内镜技术的不断进步及大量临床研究的开展,已有多种干预措施可用于食管ESD术后狭窄的预防。本文旨在通过检索近年来国内外最新文献,就ESD术后食管狭窄的预防研究进展进行综述。

Esophageal cancer which originates from esophageal mucosal epithelium is one of the most common malignant tumors. Early esophageal cancer and precancerous lesions can be cured by endoscopic minimally invasive treatment, which has the same curative effect as surgery, and has higher surgical safety and postoperative quality of life. Endoscopic submucosal dissection(ESD) is the most commonly used minimally invasive endoscopic technique. It has many advantages, but there are still some complications. Esophageal stenosis is the most common complication after ESD, which causes dysphagia and seriously affects the quality of life of patients. With the continuous progress of endoscopic technology and the development of a large number of clinical studies, a variety of interventions could be used to prevent esophageal stenosis after ESD. The purpose of this article is to review the progress of preventive measures of esophageal stenosis after ESD by searching the latest articles at home and abroad in recent years.