摘要
放射性脑损伤(RBI)是头颈部及颅内原发和继发肿瘤患者接受放疗后出现的严重并发症。关于RBI的发生机制,目前有血管损伤、炎症免疫反应和脱髓鞘等假说。其中,炎症免疫反应在RBI的发病过程中发挥着重要作用。小胶质细胞(MG)是脑内固有的免疫细胞,其在各种中枢神经系统疾病诱导的神经炎症的病理生理过程中起重要作用。笔者对近年来MG在RBI中的作用及其机制的研究进展进行综述。
Radiation-induced brain injury(RBI)is a serious complication of patients with primary and secondary tumors in the head,neck and brain after receiving radiotherapy.Regarding the mechanism of RBI,there are several hypotheses such as vascular injury,inflammatory immune response and demyelination.Among them,inflammatory response is considered to play an important role in the pathogenesis of RBI.Microglia(MG)is the innate immune cell in the brain,which plays an important role in the pathophysiology of neuroinflammation induced by various central nervous system diseases.The author summarizes the research progress of the role of MG in RBI and its mechanism in recent years.
作者
黄蓉蓉
丁桂荣
Huang Rongrong;Ding Guirong(Department of Radiation Protection Medicine,School of Military Preventive Medicine,Air Force Medical University,Xi'an 710032,China;Department of Epidemiology,Shandong First Medical University,Tai'an 271000,China)
出处
《国际放射医学核医学杂志》
2021年第2期124-131,共8页
International Journal of Radiation Medicine and Nuclear Medicine
基金
山东省自然科学基金(ZR2020MH328)。
