绞股蓝中1个新的葫芦烷型皂苷类化合物

A new cucurbitane-type saponin from Gynostemma pentaphyllum

目的对绞股蓝Gynostemma pentaphyllum的总皂苷提取物进行化学成分研究。方法综合应用多种色谱技术进行分离纯化,通过各种现代谱学技术对化合物进行结构鉴定。结果从绞股蓝的总皂苷提取物中分离得到2个葫芦烷型三萜皂苷类化合物,分别鉴定为葫芦素L-2-O-{[a-L-吡喃鼠李糖基-(1→2)][α-L-吡喃阿拉伯糖基-(1→3)]-β-D-吡喃葡萄糖基}-25-O-β-D-吡喃木糖苷(1)、葫芦素L-2-O-[α-L-吡喃鼠李糖基-(1→2)][a-L-吡喃阿拉伯糖基-(1→3)]-β-D-吡喃葡萄糖苷(2)。结论化合物1为1个新化合物,命名为绞股蓝葫芦皂苷A。

Objective To further study the chemical constituents from the total saponin extract of Jiaogulan(Gynostemma pentaphyllum). Methods The chemical constituents of G. pentaphyllum were separated and purified by chromatographic methods and structurally elucidated by means of various spectroscopic techniques. Results Two cucurbitane-type saponins were isolated from the total saponin extract of G. pentaphyllum, and identified as cucurbitacin L-2-O-{[α-L-rhamnopyranosyl-(1→2)] [α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranosyl}-25-O-β-D-xylopyranoside(1), cucurbitacin L-2-O-[a-L-rhamnopyranosyl-(1→2)] [α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside(2). Conclusion Compound 1 is a new compound named cucurbitane-gypenoside A.