血清GLDH、LAP联合GGT在慢性乙型肝炎病毒感染性肝病生化检测中的应用研究

Application of Serum GLDH,LAP combined with GGT in Biochemical Detection of Chronic Hepatitis B Virus Infectious Liver Disease

目的研究GLDH、LAP联合GGT在慢性乙型肝炎病毒感染性肝病生化检测中的应用价值。方法选择2018年6月至2019年9月共164例慢性乙型肝炎病毒感染患者作为研究组,随机选择同期160例健康体检者作为对照组,分别对两组患者的血清GLDH、LAP、GGT及肝纤维化程度进行检测。结果研究组血清中GLDH、LAP及GGT水平较对照组明显升高(P<0.05)。研究组GLDH、LAP及GGT水平呈正相关。研究组血清GLDH、LAP、GGT与透明质酸、Ⅲ型前胶原氨基端肽、Ⅳ型胶原蛋白、层粘连蛋白呈正相关(P<0.05)。结论GLDH、LAP及GGT可作为慢性乙型肝炎感染性肝病生化联合检测指标,可用于评估及判断疾病预后的参考指标。

Objective To study the application value of GLDH,LAP and GGT in biochemical detection of chronic hepatitis B virus infectious liver diseases.Methods A total of 164 patients with chronic hepatitis B virus infection from June 2018 to September 2019 were selected as the study group,and 160 healthy subjects were randomly selected as the control group.The serum GLDH,LAP,GGT and liver fibrosis degree of the two groups were detected respectively.Results GLDH,LAP and GGT water in serum of study group Ping was significantly higher than that of the control group(P<0.05).The levels of GLDH,LAP and GGT in the study group were as follows Positive correlation.Serum GLDH,LAP,GGT,hyaluronic acid and procollagen amino group of Sichuan type Terminal peptide,type I collagen,laminin.There was a positive correlation(P<0.05).Conclusion GLDH,LAP and GGT can be used as biochemical combined detection indexes for chronic hepatitis B infectious liver diseases,and can be used as reference indexes for evaluating and judging disease prognosis.