应力对椎间盘细胞调控作用的研究进展

Research progress in stress regulation of intervertebral disc cells

椎间盘由上下方的软骨终板、周围部纤维环和中央部的髓核组成,连接脊柱相邻两个椎体,在日常活动中起着承载、传递和分布载荷的作用。椎间盘受到的应力载荷是导致其发生退变的重要原因,由此引起的椎间盘退变性疾病严重影响生活质量。近年来研究表明,应力通过多种途径调控椎间盘细胞的生长和代谢,对其调控作用的深入研究有助于更好的理解椎间盘退变的过程,并为生物学治疗奠定理论基础。

The intervertebral disc is composed of the upper and lower cartilage endplates, the peripheral fibrous annulus and the central nucleus pulposus, which connects the two adjacent vertebral bodies of the spine and plays a role in carrying, transmitting and distributing loads in daily activities. The stress load on the intervertebral disc is an important reason for its degeneration, and the resulting degenerative disc disease, which seriously affects the quality of life. In recent years, studies have shown that stress regulates the growth and metabolism of intervertebral disc cells through a variety of ways. In-depth study of its regulatory effects will help to better understand the process of intervertebral disc degeneration and lay the foundation for biological treatment.