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孕晚期无乳链球菌感染的影响因素、IL-6水平及妊娠结局分析 被引量:1

Analysis of influencing factors,IL-6 levels and pregnancy outcomes of pregnant women with streptococcus agalactiae infection in the third trimester
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摘要 目的探讨孕晚期生殖道无乳链球菌感染(GBS)的影响因素、阴道分泌物中白细胞介素-6(IL-6)水平及妊娠结局。方法选取2018年12月至2019年12月在青岛市妇女儿童医院产检时发现GBS感染并接受治疗的80例孕晚期孕妇作为观察组,选取同期在我院产检并分娩的70例未感染GBS的孕晚期孕妇作为对照组。采用多因素Logistic回归分析GBS感染的影响因素,同时比较两组间阴道分泌物中IL-6的水平差异,以及两组间母儿不良妊娠结局的发生情况。结果多因素Logistic回归分析显示,有生殖道感染史(OR=2.787,95%CI:1.417~5.481)、异常的阴道清洁度(OR=3.065,95%CI:1.346~6.981)是生殖道GBS感染的独立危险因素。观察组孕妇孕晚期阴道分泌物中IL-6水平显著高于对照组(t=2.360,P<0.05)。此外,观察组中宫内感染、羊水污染、胎盘早破及产后出血的发生率显著高于对照组(χ^(2)值分别为5.596、4.762、4.717、4.863,均P<0.05),且新生儿感染及胎儿窘迫的发生率也显著高于对照组(χ^(2)值分别为4.681、4.529,均P<0.05)。结论孕晚期生殖道GBS感染可能与生殖道感染史及阴道清洁度相关,其发生可能引起阴道分泌物中IL-6水平升高,增加母儿不良妊娠结局的发生风险。 Objective To investigate the influencing factors,the levels of interleukin-6(IL-6)in vaginal secretions and the pregnancy outcomes of pregnant women with group B streptococcus(GBS)infection in the third trimester.Methods 80 cases of pregnant women in the third trimester who were diagnosed with GBS infection and received treatment in Qingdao Women and Children’s Hospital from December 2018 to December 2019 were selected as the observation group,and 70 cases of pregnant women without GBS infection in the trimester during the same period were selected as the control group.Multivariate logistic regression was used to analyze the influencing factors of GBS infection,and the differences in the level of IL-6 in vaginal secretions and adverse pregnancy outcomes between the two groups were compared.Results Multivariate logistic regression analysis showed that the history of reproductive tract infection(OR=2.787,95%CI:1.417-5.481)and abnormal vaginal cleanliness(OR=3.065,95%CI:1.346-6.981)were independent risk factors for reproductive tract GBS infection.The level of IL-6 in vaginal secretions in the observation group was significantly higher than that in the control group in the third trimester(t=2.360,P<0.05).In addition,the incidences of intrauterine infection,amniotic fluid contamination,premature rupture of placenta,and postpartum hemorrhage in the observation group were significantly higher than those in the control group(χ^(2)=5.596,4.762,4.717 and 4.863,respectively,all P<0.05),and the incidences of neonatal infection and fetal distress in the observation group were also significantly higher than those in the control group(χ^(2)=4.681 and 4.529,respectively,both P<0.05).Conclusion The incidence of reproductive tract streptococcus agalactiae infection in the third trimester might be related to the history of reproductive tract infection and vaginal cleanliness,which may increase the level of IL-6 in vaginal secretions and increase the risk of adverse pregnancy outcomes for maternal and infant.
作者 宋振霞 张静文 孙越 刘晓宁 SONG Zhenxia;ZHANG Jingwen;SUN Yue;LIU Xiaoning(Department of Obstetrics,Qingdao Women and Children’s Hospital,Shandong Qingdao 266000,China)
出处 《中国妇幼健康研究》 2021年第4期542-545,共4页 Chinese Journal of Woman and Child Health Research
基金 山东省自然科学基金(ZR2015HM035) 青岛市卫生科技计划项目(2017-WJZD113)。
关键词 孕晚期 无乳链球菌 影响因素 阴道分泌物 白细胞介素-6 妊娠结局 third trimester streptococcus agalactiae influencing factors vaginal secretions interleukin-6 pregnancy outcome
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