摘要
支气管肺发育不良(BPD)是一种以肺组织发育不全为病理基础,以肺部炎症、肺微血管发育障碍、肺泡数量减少及肺间质纤维化为病理特征的早产儿常见慢性肺部疾病。多因素均可促成早产儿BPD的形成,其中感染是一个重要因素。感染所引起的促炎细胞因子与抗炎细胞因子比例失衡会诱发早产儿的肺部炎症,促纤维化细胞因子会进一步引起早产儿BPD晚期的肺纤维化。因此,早产儿BPD的发生发展与多种细胞因子有关。该文就细胞因子在促使早产儿BPD形成过程中的作用机制进行综述。
Bronchopulmonary dysplasia(BPD)is a common chronic lung disease in preterm infants,which is based on pulmonary hypoplasia and characterized by pulmonary inflammation,pulmonary microvascular development disorder,alveolar decrease and pulmonary interstitial fibrosis.Many factors can contribute to the formation of BPD in preterm infants,among which infection is an important factor.The imbalance of pro-inflammatory cytokines and anti-inflammatory cytokines caused by infection will induce pulmonary inflammation of preterm infants,and pro-fibrotic cytokines will further cause pulmonary fibrosis in the late stage of BPD in preterm infants.Therefore,the occurrence and development of BPD in preterm infants might be related to a variety of cytokines.This paper reviews the mechanism of cytokines in promoting the formation of BPD in preterm infants.
作者
何莎莎
董文斌
HE Shasha;DONG Wenbin(Department of Neonatology,the Affiliated Hospital of Southwest Medical University,Sichuan Luzhou 646000,China;Birth Defects Clinical Medical Research Center of Sichuan Province,Sichuan Luzhou 646000,China)
出处
《中国妇幼健康研究》
2021年第4期619-625,共7页
Chinese Journal of Woman and Child Health Research
基金
国家自然科学基金资助项目(81571480)。