脉冲射频治疗带状疱疹后神经痛疗效及影响因素的回顾性分析

Efficacy and influence factors of pulsed radiofrequency in the treatment of patients with postherpetic neuralgia:a retrospective study

目的回顾性分析脉冲射频治疗带状疱疹后神经痛(PHN)的疗效及影响因素。方法收集2014年1月至2017年6月期间于山东大学附属省立医院疼痛科行脉冲射频(PRF)治疗的PHN患者79例,年龄≥50岁,性别不限,数字等级评分(NRS)≥4分,收集患者一般资料、治疗及疗效评价相关资料。比较患者治疗前与治疗后1 d、6个月时的NRS,统计6个月时疼痛缓解率,并采用多因素logistic回归分析探讨其影响因素。结果共有PHN患者62例完成研究,年龄为50~87岁,其中男30例,女32例。与治疗前相比,治疗后1 d及6个月时患者NRS评分明显降低(P均<0.05);多因素logistic回归分析显示超过6个月的长病程为独立危险因素,持续服药为其有利因素。结论PRF治疗PHN疗效明确,其中长病程预后差,而持续服用镇痛药物有助于巩固疗效。

Objective To retrospectively analyze the efficacy and influence factors of pulsed radiofrequency for postherpetic neuralgia.Methods Seventy-nine patients with postherpetic neuralgia(PHN),aged≥50 years old,both sexes,NRS≥4 underwent pulsed radiofrequency(PRF)treatment in the Department of Pain Management,Shandong Provincial Hospital from January 2014 to June 2017,were analysed.General data,treatment and efficacy evaluation were collected.VAS was recorded before the treatment,1 day and 6 months after the treatment.The remission rate was calculated,and risk factors were analysed by logistic regression analysis.Results Only sixty-two patients with PHN were included according to follow-up criteria,aged 50-87 years old,30 males and 32 females.Compared with pre-treatment,NRS was significantly lower at 1 day and 6 months after the treatment(all P<0.05).Multivariate logistic regression analysis showed that the disease duration of more than 6 months was a risk factor for effectiveness,and continuous medication was a favorable factor.Conclusion PRF is effective for patients with PHN,and long course of disease is a risk factor,and continuous medication is a favorable factor.