摘要
循环肿瘤细胞(CTC)作为一种新兴的肿瘤标志物,其稀有性和异质性增加了检测的难度。近年来依据生物物理特性、生物化学特性及微流控的CTC富集技术不断发展,促进了CTC在恶性肿瘤辅助诊断、临床治疗和预后评价等方面的研究和应用。CTC的检测目前仍存在一些不足,但随着多学科交叉融合,CTC在恶性肿瘤的辅助诊断、治疗等方面将发挥更大的作用。
As an emerging tumor marker,the rarity and heterogeneity of circulating tumor cells(CTCs)increase the difficulty of detection.In recent years,CTCs enrichment technology based on biophysical,biochemical and microfluidic properties has been continuously developed,which has promoted the research and application of CTCs in malignant tumors diagnosis,clinical treatment and prognosis evaluation.Although there are still some deficiencies in the detection of CTCs,with the interdisciplinary integration,CTCs will play increasingly important roles in the diagnosis and treatment of malignant tumors.
作者
宁大为
欧洋
崔凯
李胜
高德海
Ning Dawei;Ou Yang;Cui Kai;Li Sheng;Gao Dehai(Department of Hepatobiliary Surgery,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,China;Department of General Surgery,Fifth People′s Hospital of Jinan,Jinan 250022,China;Department of Achievements Transformation and Industry(Serving Local Economic Office),Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250021,China)
出处
《国际肿瘤学杂志》
CAS
2021年第3期167-171,共5页
Journal of International Oncology
基金
山东第一医科大学学术提升计划(2019QL004)
2019年度济南市"高校20条"资助项目(2019GXRC020)
山东省重点研发计划(2017CXGC1204)。
关键词
肿瘤细胞
循环
生物标记
细胞学技术
诊断
Neoplastic cells,circulating
Biomarkers
Cytological techniques
Diagnosis
