干扰素及其相关信号通路抑制脑胶质瘤侵袭的机制

Mechanism of inhibitory effect of interferon and its related signal pathway on the invasion of glioma

胶质瘤是颅内发生率较高的肿瘤,其恶性程度高、侵袭性强、致死率高等特点使目前常规治疗方法并不能达到预期的治疗效果,极大地影响患者的生命质量。干扰素作为一种具有抗增殖、抑制血管新生、抑制侵袭等作用的蛋白质,在临床中广泛应用于各种肿瘤的治疗。不少研究表明干扰素在胶质瘤的发生发展过程中起重要作用。探讨干扰素及其相关信号通路在胶质瘤侵袭过程中的作用机制,研究新的胶质瘤治疗方案在临床治疗中显得十分必要。

Glioma is a tumor with a high incidence of intracranial tumor.Because of its high degree of malignancy,strong invasiveness and high mortality,the current conventional treatment cannot achieve the desired therapeutic effect,which greatly affects the quality of life of patients.As a protein with the functions of anti-proliferation,anti-angiogenesis and anti-invasion,interferon is widely used in the treatment of all kinds of tumors in clinic.Many studies have shown that interferon plays an important role in the occurrence and development of gliomas.To explore the mechanism of interferon and its related signal pathway in the process of glioma invasion,and to study the new treatment of glioma is very necessary in clinical treatment.